发明申请
- 专利标题： Pharmaceutical composition and therapeutic method
- 专利标题（中）： 药物组成及治疗方法
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申请号： US11596674申请日： 2005-05-17
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公开(公告)号： US20090016987A1公开(公告)日： 2009-01-15
- 发明人: Naoki Aikawa , Seitaro Fujishima , Kazuhiko Sekine
- 申请人： Naoki Aikawa , Seitaro Fujishima , Kazuhiko Sekine
- 申请人地址： JP MINATIO-KU TOKYO
- 专利权人： KEIO UNIVERSITY
- 当前专利权人： KEIO UNIVERSITY
- 当前专利权人地址： JP MINATIO-KU TOKYO
- 优先权： FI20040694 20040518
- 国际申请： PCT/JP05/08944 WO 20050517
- 主分类号： C07K14/54
- IPC分类号： C07K14/54 ; A61K38/21 ; A61P29/00
摘要：
The object of the present invention is, based on the finding of a novel effect of IL-18, to provide pharmaceutical compositions containing IL-18 and therapeutic methods, for preventing, improving, or treating inflammatory diseases such as systemic inflammatory response syndrome (SIRS). Inflammatory diseases, such as SIRS, can be prevented, improved, or treated by administering the pharmaceutical compositions according to the present invention containing IL-18 in an amount which does not bring the decreased interleukin 18 level in either plasma or liver to a higher level than normal.