发明申请
- 专利标题： Multiple Component Nanoparticles for Multiplexed Signaling and Optical Encoding
- 专利标题（中）： 用于复用信令和光编码的多组分纳米颗粒
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申请号： US12066308申请日： 2006-10-10
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公开(公告)号： US20090017476A1公开(公告)日： 2009-01-15
- 发明人: Weihong Tan , Lin Wang , Chaoyong Yang
- 申请人： Weihong Tan , Lin Wang , Chaoyong Yang
- 国际申请： PCT/US2006/039535 WO 20061010
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; B32B1/00
摘要：
The present invention provides multiple-luminophore silica nanoparticles for multiplexed signaling in bioanalysis. In specific embodiments, two inorganic luminophores, Tris(2,2′-bipyridyl)osmium(II) bis(hexafluorophosphate) (OsBpy) and Tris(2,2′-bipyridyl)dichlororuthenium(II) hexahydrate (RuBpy), or three organic luminophores 5-Fluorescein isothiocyanate (5-FITC), 5-carboxyrhodamine 6G, succinimidyl ester (5-CR6G, SE), 6-carboxy-X-rhodamine, succinimidyl ester (6-ROX, SE) can be simultaneously entrapped inside silica nanoparticles at controlled ratios, with desirable sizes and required surface functionality. Single-wavelength excitation with multiple emission endows the nanoparticles with optical encoding capability for rapid and high-throughput multiplexed detection.
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