发明申请
US20090023676A1 RNA Interference Mediated Inhibition of MAP Kinase Gene Expression or Expression of Genes Involved in MAP Kinase Pathway Using Short Interfering Nucleic Acid (SiNA)
审中-公开
RNA干扰介导MAP激酶基因表达的抑制或涉及使用短干扰核酸（SiNA）的MAP激酶途径的基因表达
- 专利标题： RNA Interference Mediated Inhibition of MAP Kinase Gene Expression or Expression of Genes Involved in MAP Kinase Pathway Using Short Interfering Nucleic Acid (SiNA)
- 专利标题（中）： RNA干扰介导MAP激酶基因表达的抑制或涉及使用短干扰核酸（SiNA）的MAP激酶途径的基因表达
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申请号： US12201759申请日： 2008-08-29
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公开(公告)号： US20090023676A1公开(公告)日： 2009-01-22
- 发明人: James McSwiggen , Leonid Beigelman , Nassim Usman , Peter Haeberli , Bharat M. Chowrira , Barry Polisky
- 申请人： James McSwiggen , Leonid Beigelman , Nassim Usman , Peter Haeberli , Bharat M. Chowrira , Barry Polisky
- 申请人地址： US CA San Francisco
- 专利权人： Sirna Therapeutics, Inc.
- 当前专利权人： Sirna Therapeutics, Inc.
- 当前专利权人地址： US CA San Francisco
- 主分类号： A61K31/7088
- IPC分类号： A61K31/7088 ; C07H21/02
摘要：
The present invention concerns methods and reagents useful in modulating MAP kinase gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against c-JUN, JNK, p38, and ERK gene expression, useful in the treatment of cancer, inflammation, obesity and insulin resistance (e.g. Type I and Type II diabetes).
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