公开(公告)号：US20090023676A1

公开(公告)日：2009-01-22

申请号：US12201759

申请日：2008-08-29

申请人： James McSwiggen ,  Leonid Beigelman ,  Nassim Usman ,  Peter Haeberli ,  Bharat M. Chowrira ,  Barry Polisky

发明人： James McSwiggen ,  Leonid Beigelman ,  Nassim Usman ,  Peter Haeberli ,  Bharat M. Chowrira ,  Barry Polisky

IPC分类号： A61K31/7088 ,  C07H21/02

CPC分类号： C12N15/8218 ,  A61K38/00 ,  A61K47/54 ,  C07H21/02 ,  C12N15/111 ,  C12N15/1131 ,  C12N15/1138 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/318 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/332 ,  C12N2310/344 ,  C12N2310/346 ,  C12N2310/53 ,  C12N2320/51 ,  C12N2330/30 ,  Y02A50/393 ,  C12N2310/3521

摘要： The present invention concerns methods and reagents useful in modulating MAP kinase gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against c-JUN, JNK, p38, and ERK gene expression, useful in the treatment of cancer, inflammation, obesity and insulin resistance (e.g. Type I and Type II diabetes).

摘要翻译： 本发明涉及可用于在各种应用中调节MAP激酶基因表达的方法和试剂，包括用于治疗，诊断，靶标验证和基因组发现应用。 具体而言，本发明涉及小核酸分子，如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA） 能够介导针对c-JUN，JNK，p38和ERK基因表达的RNA干扰（RNAi）的分子，可用于治疗癌症，炎症，肥胖和胰岛素抵抗（例如I型和II型糖尿病）。

公开(公告)号：US20090137500A1

公开(公告)日：2009-05-28

申请号：US10720448

申请日：2003-11-24

申请人： James McSwiggen ,  Bharat M. Chowrira ,  Leonid Beigelman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrisey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weiman Wang ,  Tongqian Chen ,  Narendra Vaish

发明人： James McSwiggen ,  Bharat M. Chowrira ,  Leonid Beigelman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrisey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weiman Wang ,  Tongqian Chen ,  Narendra Vaish

IPC分类号： A61K31/713 ,  C07H21/02

CPC分类号： C12N15/113 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/321 ,  C12N2310/3521

摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.

摘要翻译： 本发明涉及可用于调节各种应用中的基因表达的方法和试剂，包括在治疗，诊断，靶标验证和基因组发现应用中的用途。 具体地，本发明涉及合成的化学修饰的小核酸分子，例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA （shRNA）分子，其能够介导针对靶核酸序列的RNA干扰（RNAi）。 小核酸分子可用于治疗对细胞，组织或生物中的基因表达或活性的调节作出反应的任何疾病或病症。

公开(公告)号：US20060127891A1

公开(公告)日：2006-06-15

申请号：US10424339

申请日：2003-04-25

申请人： James McSwiggen ,  Leonid Beigelman ,  Nassim Usman ,  Peter Haeberli ,  Bharat Chowrira ,  Barry Polisky

发明人： James McSwiggen ,  Leonid Beigelman ,  Nassim Usman ,  Peter Haeberli ,  Bharat Chowrira ,  Barry Polisky

IPC分类号： A61K48/00 ,  C07H21/02 ,  C12Q1/68

CPC分类号： C12N15/115 ,  A61K38/00 ,  A61K47/54 ,  C12N15/1137 ,  C12N15/1138 ,  C12N2310/111 ,  C12N2310/12 ,  C12N2310/121 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/318 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/332 ,  C12N2310/346 ,  C12N2310/53 ,  C12Y104/03003 ,  C12Y114/19001 ,  C12Y207/11001 ,  C12Y207/11013 ,  C12Y301/03048 ,  C12N2310/3521

摘要： The present invention concerns methods and reagents useful in modulating MAP kinase gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against c-JUN, JNK, p38, and ERK gene expression, useful in the treatment of cancer, inflammation, obesity and insulin resistance (e.g. Type I and Type II diabetes).

摘要翻译： 本发明涉及可用于在各种应用中调节MAP激酶基因表达的方法和试剂，包括用于治疗，诊断，靶标验证和基因组发现应用。 具体而言，本发明涉及小核酸分子，如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA（shRNA） 能够介导针对c-JUN，JNK，p38和ERK基因表达的RNA干扰（RNAi）的分子，可用于治疗癌症，炎症，肥胖和胰岛素抵抗（例如I型和II型糖尿病）。

公开(公告)号：US20060281175A1

公开(公告)日：2006-12-14

申请号：US11502876

申请日：2006-08-11

申请人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra Vaish

发明人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra Vaish

IPC分类号： C12N5/06 ,  A61K48/00 ,  C07H21/02 ,  C07F9/6512

CPC分类号： C07F9/65616 ,  A61K9/0019 ,  A61K47/544 ,  A61K47/549 ,  A61K47/554 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2320/51 ,  C12N2330/30 ,  Y02A50/465 ,  C12N2310/3521

摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.

公开(公告)号：US20060217335A1

公开(公告)日：2006-09-28

申请号：US11358807

申请日：2006-02-21

申请人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra Vaish

发明人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra Vaish

IPC分类号： A61K48/00 ,  C07H21/00 ,  C07F9/6512

CPC分类号： C07F9/65616 ,  A61K9/0019 ,  A61K47/544 ,  A61K47/549 ,  A61K47/554 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2320/51 ,  C12N2330/30 ,  Y02A50/465 ,  C12N2310/3521

摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.

公开(公告)号：US20050020525A1

公开(公告)日：2005-01-27

申请号：US10757803

申请日：2004-01-14

申请人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimen Wang ,  Tonqian Chen ,  Narendra Vaish

发明人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimen Wang ,  Tonqian Chen ,  Narendra Vaish

IPC分类号： A61K38/00 ,  A61K47/48 ,  C12N15/113 ,  C12N15/87 ,  A61K48/00 ,  C07H21/02

CPC分类号： A61K49/0008 ,  A61K38/00 ,  A61K47/544 ,  A61K47/549 ,  A61K47/551 ,  A61K47/554 ,  A61K47/59 ,  A61K47/60 ,  A61K47/64 ,  A61K47/645 ,  C12N15/113 ,  C12N15/87 ,  C12N2310/111 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2310/315 ,  C12N2310/318 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/332 ,  C12N2310/346 ,  C12N2310/53 ,  C12N2310/3521

摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.

摘要翻译： 本发明涉及可用于调节各种应用中的基因表达的方法和试剂，包括在治疗，诊断，靶标验证和基因组发现应用中的用途。 具体地，本发明涉及合成的化学修饰的小核酸分子，例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA （shRNA）分子，其能够介导针对靶核酸序列的RNA干扰（RNAi）。 小核酸分子可用于治疗对细胞，组织或生物中的基因表达或活性的调节作出反应的任何疾病或病症。

公开(公告)号：US08846894B2

公开(公告)日：2014-09-30

申请号：US11676124

申请日：2007-02-16

申请人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon F Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra K Vaish

发明人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon F Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra K Vaish

IPC分类号： A61K48/00 ,  C07H21/02 ,  C07H21/04

CPC分类号： C07F9/65616 ,  A61K9/0019 ,  A61K47/544 ,  A61K47/549 ,  A61K47/554 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2320/51 ,  C12N2330/30 ,  Y02A50/465 ,  C12N2310/3521

摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.

摘要翻译： 本发明涉及可用于调节各种应用中的基因表达的方法和试剂，包括在治疗，诊断，靶标验证和基因组发现应用中的用途。 具体地，本发明涉及合成的化学修饰的小核酸分子，例如短干扰核酸（siNA），短干扰RNA（siRNA），双链RNA（dsRNA），微RNA（miRNA）和短发夹RNA （shRNA）分子，其能够介导针对靶核酸序列的RNA干扰（RNAi）。 小核酸分子可用于治疗对细胞，组织或生物中的基因表达或活性的调节作出反应的任何疾病或病症。

公开(公告)号：US20070004663A1

公开(公告)日：2007-01-04

申请号：US11499520

申请日：2006-08-04

申请人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra Vaish

发明人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra Vaish

IPC分类号： A61K48/00 ,  C07H21/02 ,  C07F9/6512

CPC分类号： C07F9/65616 ,  A61K9/0019 ,  A61K47/544 ,  A61K47/549 ,  A61K47/554 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2320/51 ,  C12N2330/30 ,  Y02A50/465 ,  C12N2310/3521

摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.

公开(公告)号：US20060293271A1

公开(公告)日：2006-12-28

申请号：US11499521

申请日：2006-08-04

申请人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra Vaish

发明人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis Macejak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra Vaish

IPC分类号： A61K48/00 ,  C07H21/02 ,  C07F9/6512

CPC分类号： C07F9/65616 ,  A61K9/0019 ,  A61K47/544 ,  A61K47/549 ,  A61K47/554 ,  C12N15/111 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2320/51 ,  C12N2330/30 ,  Y02A50/465 ,  C12N2310/3521

摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.

公开(公告)号：US20060276635A1

公开(公告)日：2006-12-07

申请号：US11499828

申请日：2006-08-04

申请人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis MacEjak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra Vaish

发明人： James McSwiggen ,  Bharat Chowrira ,  Leonid Beigelman ,  Dennis MacEjak ,  Shawn Zinnen ,  Pamela Pavco ,  Peter Haeberli ,  David Morrissey ,  Kathy Fosnaugh ,  Sharon Jamison ,  Nassim Usman ,  James Thompson ,  Chandra Vargeese ,  Weimin Wang ,  Tongqian Chen ,  Narendra Vaish

IPC分类号： C07H21/02

CPC分类号： C12N15/111 ,  A61K9/0019 ,  A61K9/0048 ,  A61K47/544 ,  A61K47/549 ,  A61K47/554 ,  C12N2310/14 ,  C12N2310/315 ,  C12N2310/317 ,  C12N2310/321 ,  C12N2310/322 ,  C12N2310/346 ,  C12N2310/351 ,  C12N2320/51 ,  C12N2310/3521

摘要： The present invention concerns methods and reagents useful in modulating gene expression in a variety of applications, including use in therapeutic, diagnostic, target validation, and genomic discovery applications. Specifically, the invention relates to synthetic chemically modified small nucleic acid molecules, such as short interfering nucleic acid (siNA), short interfering RNA (siRNA), double-stranded RNA (dsRNA), micro-RNA (miRNA), and short hairpin RNA (shRNA) molecules capable of mediating RNA interference (RNAi) against target nucleic acid sequences. The small nucleic acid molecules are useful in the treatment of any disease or condition that responds to modulation of gene expression or activity in a cell, tissue, or organism.