发明申请
- 专利标题： Intercellular adhesion molecules and their binding ligands
- 专利标题（中）： 细胞间粘附分子及其结合配体
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申请号： US11633078申请日： 2006-12-04
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公开(公告)号： US20090035321A1公开(公告)日： 2009-02-05
- 发明人: Timothy A. Springer , Robert Rothlein , Steven D. Marlin , Michael L. Dustin
- 申请人： Timothy A. Springer , Robert Rothlein , Steven D. Marlin , Michael L. Dustin
- 专利权人： Boehringer Ingelheim Pharmaceuticals, Inc.
- 当前专利权人： Boehringer Ingelheim Pharmaceuticals, Inc.
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K14/47 ; C07H21/04 ; C07K1/22 ; C12Q1/02
摘要：
The present invention relates to intercellular adhesion molecules (ICAM-1) which are involved in the process through which lymphocytes recognize and migrate to sites of inflammation as well as attach to cellular substrates during inflammation. The invention is directed toward such molecules, screening assays for identifying such molecules and antibodies capable of binding such molecules. The invention also includes uses for adhesion molecules and for the antibodies that are capable of binding them.