发明申请
- 专利标题: MONOAMIDE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS
- 专利标题(中): 单酰胺衍生物作为OREXIN受体拮抗剂
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申请号: US12178688申请日: 2008-07-24
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公开(公告)号: US20090036422A1公开(公告)日: 2009-02-05
- 发明人: Henner Knust , Matthias Nettekoven , Emmanuel Pinard , Olivier Roche , Mark Rogers-Evans
- 申请人: Henner Knust , Matthias Nettekoven , Emmanuel Pinard , Olivier Roche , Mark Rogers-Evans
- 优先权: EP07113702.0 20070802
- 主分类号: A61K31/397
- IPC分类号: A61K31/397 ; A61K31/165 ; A61K31/52 ; A61K31/437 ; C07C233/88 ; C07D471/04 ; C07D487/04 ; C07D491/107
摘要:
The present invention relates to compounds of formula wherein Ar, R1, R2, R3, R4, R5, n, o, and p are as defined herein or to pharmaceutically suitable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof. The compounds of formula I can be used for the treatment of sleep disorders, such as sleep apnea, narcolepsy, insomnia, parasomnia, jet lag syndrome, circadian rhythms disorder or sleep disorders associated with neurological diseases.
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