发明申请
- 专利标题： Method of immunizing animal, composition for immunization, method for producing antibody, method for producing hybridoma and method for producing monoclonal antibody
- 专利标题（中）： 动物免疫方法，免疫组合物，抗体制造方法，杂交瘤的制造方法及单克隆抗体的制造方法
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申请号： US11665270申请日： 2005-10-14
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公开(公告)号： US20090041761A1公开(公告)日： 2009-02-12
- 发明人: Joe Chiba , Jun-ichi Hata , Naoki Nishiguchi , Masahiro Furutani
- 申请人： Joe Chiba , Jun-ichi Hata , Naoki Nishiguchi , Masahiro Furutani
- 优先权： JP2004-301887 20041015
- 国际申请： PCT/JP2005/018953 WO 20051014
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K39/00 ; C12N5/16 ; A61P31/00 ; C12P21/08
摘要：
It is an object of the present invention to a method whereby a humoral immune response is induced more efficiently in producing an antibody against an antigen protein by gene immunization. A fusion gene composed of a gene encoding the full-length of a part of the antigen protein or a gene encoding a chaperonin subunit or a chaperonin subunit linkage linked thereto is administered to express the fusion gene in the animal, thereby inducing a humoral immune response to an antigen protein by administering. An example of the chaperonin includes Escherichia coli GroEL. There is also provided with a composition for immunization, a method for producing an antibody, a method for producing a hybridoma, and a method for producing a monoclonal antibody.
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