发明申请
- 专利标题: Nucleic Acid-Lipopolymer Compositions
- 专利标题(中): 核酸 - 脂质聚合物组合物
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申请号: US12186945申请日: 2008-08-06
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公开(公告)号: US20090042829A1公开(公告)日: 2009-02-12
- 发明人: Majed Matar , Jason Fewell , Danny H. Lewis , Khursheed Anwer
- 申请人: Majed Matar , Jason Fewell , Danny H. Lewis , Khursheed Anwer
- 主分类号: A61K31/70
- IPC分类号: A61K31/70 ; C12N15/63 ; A61P43/00
摘要:
Compositions, methods, and applications that increase the efficiency of nucleic acid transfection are provided. In one aspect, a pharmaceutical composition may include at least about 0.5 mg/ml concentration of a nucleic acid condensed with a cationic lipopolymer suspended in an isotonic solution, where the cationic lipopolymer includes a cationic polymer backbone having cholesterol and polyethylene glycol covalently attached thereto, and wherein the molar ratio of cholesterol to cationic polymer backbone is within a range of from about 0.1 to about 10, and the molar ratio of polyethylene glycol to cationic polymer backbone is within a range of from about 0.1 to about 10. The composition further may include a filler excipient.
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