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公开(公告)号：US20130065942A1
公开(公告)日：2013-03-14
申请号：US13605462
申请日：2012-09-06
申请人： Majed Matar , Jason Fewell , Danny H. Lewis , Khursheed Anwer
发明人： Majed Matar , Jason Fewell , Danny H. Lewis , Khursheed Anwer
IPC分类号： A61K31/7105 , A61K48/00 , C12N15/88
CPC分类号： A61K48/0041 , A61K9/0019 , A61K9/1272 , A61K9/19 , A61K31/70 , A61K38/00 , A61K38/208 , A61K47/26 , A61K47/36 , A61K47/38 , A61K47/554 , A61K47/59 , A61K47/60 , A61K47/6455 , A61K48/0075 , C12N5/00 , C12N15/111 , C12N15/113 , C12N15/88 , C12N2310/14 , C12N2320/32 , C12N2510/00
摘要： Compositions, methods, and applications that increase the efficiency of nucleic acid transfection are provided. In one aspect, a pharmaceutical composition may include at least about 0.5 mg/ml concentration of a nucleic acid condensed with a cationic lipopolymer suspended in an isotonic solution, where the cationic lipopolymer includes a cationic polymer backbone having cholesterol and polyethylene glycol covalently attached thereto, and wherein the molar ratio of cholesterol to cationic polymer backbone is within a range of from about 0.1 to about 10, and the molar ratio of polyethylene glycol to cationic polymer backbone is within a range of from about 0.1 to about 10. The composition further may include a filler excipient.
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公开(公告)号：US09144546B2
公开(公告)日：2015-09-29
申请号：US13605462
申请日：2012-09-06
申请人： Majed Matar , Jason Fewell , Danny H. Lewis , Khursheed Anwer
发明人： Majed Matar , Jason Fewell , Danny H. Lewis , Khursheed Anwer
IPC分类号： A61K31/7105 , A61K48/00 , C12N15/88 , A61K9/19 , A61K9/00 , A61K9/127 , A61K31/70 , A61K47/26 , A61K47/36 , A61K47/38 , A61K47/48
CPC分类号： A61K48/0041 , A61K9/0019 , A61K9/1272 , A61K9/19 , A61K31/70 , A61K38/00 , A61K38/208 , A61K47/26 , A61K47/36 , A61K47/38 , A61K47/554 , A61K47/59 , A61K47/60 , A61K47/6455 , A61K48/0075 , C12N5/00 , C12N15/111 , C12N15/113 , C12N15/88 , C12N2310/14 , C12N2320/32 , C12N2510/00
摘要： Compositions, methods, and applications that increase the efficiency of nucleic acid transfection are provided. In one aspect, a pharmaceutical composition may include at least about 0.5 mg/ml concentration of a nucleic acid condensed with a cationic lipopolymer suspended in an isotonic solution, where the cationic lipopolymer includes a cationic polymer backbone having cholesterol and polyethylene glycol covalently attached thereto, and wherein the molar ratio of cholesterol to cationic polymer backbone is within a range of from about 0.1 to about 10, and the molar ratio of polyethylene glycol to cationic polymer backbone is within a range of from about 0.1 to about 10. The composition further may include a filler excipient.
摘要翻译： 提供了提高核酸转染效率的组合物，方法和应用。 一方面，药物组合物可以包含至少约0.5mg / ml浓度的悬浮在等渗溶液中的阳离子脂质聚合物浓缩的核酸，其中阳离子脂质聚合物包括具有共价连接到其上的胆固醇和聚乙二醇的阳离子聚合物骨架， 并且其中胆固醇与阳离子聚合物主链的摩尔比在约0.1至约10的范围内，聚乙二醇与阳离子聚合物主链的摩尔比在约0.1至约10的范围内。组合物还可以 包括填充剂赋形剂。
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3.发明申请Composition, method of preparation & application of concentrated formulations of condensed nucleic acids with a cationic lipopolymer 审中-公开组合物，制备和应用浓缩核酸与阳离子脂质聚合物的配制方法公开(公告)号：US20090042825A1
公开(公告)日：2009-02-12
申请号：US11890805
申请日：2007-08-06
申请人： Majed Matar , Jason Fewell , Danny H. Lewis , Khursheed Anwer
发明人： Majed Matar , Jason Fewell , Danny H. Lewis , Khursheed Anwer
CPC分类号： A61K48/0041 , A61K9/0019 , A61K9/1272 , A61K9/19 , A61K31/70 , A61K38/00 , A61K38/208 , A61K47/26 , A61K47/36 , A61K47/38 , A61K47/554 , A61K47/59 , A61K47/60 , A61K47/6455 , A61K48/0075 , C12N5/00 , C12N15/111 , C12N15/113 , C12N15/88 , C12N2310/14 , C12N2320/32 , C12N2510/00
摘要： Compositions, methods, and applications that increase the efficiency of nucleic acid transfection are provided. In one aspect, a pharmaceutical composition may include at least about 0.5 mg/ml concentration of a nucleic acid condensed with a cationic lipopolymer suspended in an isotonic solution, where the cationic lipopolymer includes a cationic polymer backbone having cholesterol and polyethylene glycol covalently attached thereto, and wherein the molar ratio of cholesterol to cationic polymer backbone is within a range of from about 0.1 to about 10, and the molar ratio of polyethylene glycol to cationic polymer backbone is within a range of from about 0.1 to about 10. The composition further may include a filler excipient.
摘要翻译： 提供了提高核酸转染效率的组合物，方法和应用。 一方面，药物组合物可以包含至少约0.5mg / ml浓度的悬浮在等渗溶液中的阳离子脂质聚合物浓缩的核酸，其中阳离子脂质聚合物包括具有共价连接到其上的胆固醇和聚乙二醇的阳离子聚合物骨架， 并且其中胆固醇与阳离子聚合物主链的摩尔比在约0.1至约10的范围内，并且聚乙二醇与阳离子聚合物主链的摩尔比在约0.1至约10的范围内。组合物还可以 包括填充剂赋形剂。
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公开(公告)号：US20090042829A1
公开(公告)日：2009-02-12
申请号：US12186945
申请日：2008-08-06
申请人： Majed Matar , Jason Fewell , Danny H. Lewis , Khursheed Anwer
发明人： Majed Matar , Jason Fewell , Danny H. Lewis , Khursheed Anwer
CPC分类号： A61K48/0041 , A61K9/0019 , A61K9/1272 , A61K9/19 , A61K31/70 , A61K38/00 , A61K38/208 , A61K47/26 , A61K47/36 , A61K47/38 , A61K47/554 , A61K47/59 , A61K47/60 , A61K47/6455 , A61K48/0075 , C12N5/00 , C12N15/111 , C12N15/113 , C12N15/88 , C12N2310/14 , C12N2320/32 , C12N2510/00
摘要： Compositions, methods, and applications that increase the efficiency of nucleic acid transfection are provided. In one aspect, a pharmaceutical composition may include at least about 0.5 mg/ml concentration of a nucleic acid condensed with a cationic lipopolymer suspended in an isotonic solution, where the cationic lipopolymer includes a cationic polymer backbone having cholesterol and polyethylene glycol covalently attached thereto, and wherein the molar ratio of cholesterol to cationic polymer backbone is within a range of from about 0.1 to about 10, and the molar ratio of polyethylene glycol to cationic polymer backbone is within a range of from about 0.1 to about 10. The composition further may include a filler excipient.
摘要翻译： 提供了提高核酸转染效率的组合物，方法和应用。 一方面，药物组合物可以包含至少约0.5mg / ml浓度的悬浮在等渗溶液中的阳离子脂质聚合物浓缩的核酸，其中阳离子脂质聚合物包括具有共价连接到其上的胆固醇和聚乙二醇的阳离子聚合物骨架， 并且其中胆固醇与阳离子聚合物主链的摩尔比在约0.1至约10的范围内，聚乙二醇与阳离子聚合物主链的摩尔比在约0.1至约10的范围内。组合物还可以 包括填充剂赋形剂。
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公开(公告)号：US20130251809A1
公开(公告)日：2013-09-26
申请号：US13791102
申请日：2013-03-08
申请人： Gregory Slobodkin , Richard Congo , Majed Matar , Jason Fewell , Khursheed Anwer , Brian Jeffery Sparks
发明人： Gregory Slobodkin , Richard Congo , Majed Matar , Jason Fewell , Khursheed Anwer , Brian Jeffery Sparks
CPC分类号： A61K47/48061 , A61K9/1272 , A61K31/7088 , A61K31/713 , A61K47/16 , A61K47/542 , A61K47/6911 , C07C233/38 , C07C235/10 , C07C235/60 , C07D475/04 , C07H15/10 , C07K7/23 , C07K7/64
摘要： Disclosed are compounds, compositions and methods for systemic and local delivery of biologically active molecules.
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公开(公告)号：US20100004313A1
公开(公告)日：2010-01-07
申请号：US12395240
申请日：2009-02-27
CPC分类号： C08G65/329 , A61K9/0019 , A61K47/34
摘要： Nucleotide delivery polymers, compositions, and associated methods for the enhancement of gene delivery and expression in solid tissues are provided. In one aspect, for example, a nucleotide delivery polymer may include a poloxamer backbone having a metal chelator covalently coupled to at least one terminal end of the poloxamer backbone. In another aspect, the nucleotide expression polymer has a metal chelator coupled to at least two terminal ends of the poloxamer backbone.
摘要翻译： 提供了用于增强固体组织中基因递送和表达的核苷酸递送聚合物，组合物和相关方法。 在一个方面，例如，核苷酸递送聚合物可以包括具有与泊洛沙姆主链的至少一个末端共价连接的金属螯合剂的泊洛沙姆骨架。 另一方面，核苷酸表达聚合物具有与泊洛沙姆主链的至少两个末端偶联的金属螯合剂。
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公开(公告)号：US20100260817A1
公开(公告)日：2010-10-14
申请号：US12727987
申请日：2010-03-19
申请人： Gregory Slobodkin , Richard Congo , Majed Matar , Jason Fewell , Khursheed Anwer , Brian Jeffery Sparks
发明人： Gregory Slobodkin , Richard Congo , Majed Matar , Jason Fewell , Khursheed Anwer , Brian Jeffery Sparks
IPC分类号： A61F2/00 , C07C233/38 , C07D475/04 , A61K31/713 , A61K31/711 , C07K7/23 , C07H15/10 , C07K7/06 , A61P35/00 , A61P31/12 , A61P35/04 , A61P27/02 , A61P13/12
CPC分类号： A61K47/48061 , A61K9/1272 , A61K31/7088 , A61K31/713 , A61K47/16 , A61K47/542 , A61K47/6911 , C07C233/38 , C07C235/10 , C07C235/60 , C07D475/04 , C07H15/10 , C07K7/23 , C07K7/64
摘要： Disclosed are compounds, compositions and methods for systemic and local delivery of biologically active molecules.
摘要翻译： 公开了用于全身和局部递送生物活性分子的化合物，组合物和方法。
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8.发明申请Combination of immuno gene therapy & chemotherapy for treatment of cancer & hyperproliferative diseases 有权免疫基因治疗与化疗联合用于治疗癌症和过度增殖性疾病公开(公告)号：US20060127482A1
公开(公告)日：2006-06-15
申请号：US11261931
申请日：2005-10-28
申请人： Jason Fewell , Majed Matar , Jennifer Rice , Danny Lewis , Khursheed Anwer
发明人： Jason Fewell , Majed Matar , Jennifer Rice , Danny Lewis , Khursheed Anwer
IPC分类号： A61K48/00 , A61K31/7076 , A61K31/7072 , A61K31/704 , A61K31/4745 , A61K31/337 , A61K9/14 , A61K31/28 , A61K33/24
CPC分类号： A61K47/34 , A61K9/0019 , A61K9/0085 , A61K31/17 , A61K31/28 , A61K31/337 , A61K31/4745 , A61K31/664 , A61K31/704 , A61K31/7068 , A61K31/7072 , A61K31/7076 , A61K33/24 , A61K38/208 , A61K39/39558 , A61K47/10 , A61K47/6951 , A61K48/0041 , A61K48/005 , B82Y5/00 , C12N15/87 , A61K2300/00
摘要： Pharmaceutical compositions comprising a nucleic acid, a gene delivery polymer, and at least one adjunctive chemotherapeutic drug for the treatment of mammalian cancer or hyperproliferative disorders and methods of using thereof for the treatment of mammalian cancer or hyperproliferative disorders by intratumoral, intraperitoneal or systemic injection.
摘要翻译： 包含核酸，基因递送聚合物和用于治疗哺乳动物癌症或过度增殖性病症的至少一种辅助化学治疗药物的药物组合物及其用于通过肿瘤内，腹膜内或全身注射治疗哺乳动物癌症或过度增殖性疾病的方法。
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公开(公告)号：US20140050775A1
公开(公告)日：2014-02-20
申请号：US13790980
申请日：2013-03-08
申请人： Gregory Slobodkin , Richard Congo , Majed Matar , Jason Fewell , Khursheed Anwer , Brian Jeffery Sparks
发明人： Gregory Slobodkin , Richard Congo , Majed Matar , Jason Fewell , Khursheed Anwer , Brian Jeffery Sparks
IPC分类号： C07C233/38 , C07H15/10 , A61K9/127 , C07K7/64 , A61K31/713 , C07D475/04 , C07K7/23
CPC分类号： A61K47/48061 , A61K9/1272 , A61K31/7088 , A61K31/713 , A61K47/16 , A61K47/542 , A61K47/6911 , C07C233/38 , C07C235/10 , C07C235/60 , C07D475/04 , C07H15/10 , C07K7/23 , C07K7/64
摘要： Disclosed are compounds, compositions and methods for systemic and local delivery of biologically active molecules.
摘要翻译： 公开了用于全身和局部递送生物活性分子的化合物，组合物和方法。
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10.发明申请公开(公告)号：US20060093674A1
公开(公告)日：2006-05-04
申请号：US10981135
申请日：2004-11-03
申请人： Gregory Slobodkin , Majed Matar , Jason Fewell , Khursheed Anwer
发明人： Gregory Slobodkin , Majed Matar , Jason Fewell , Khursheed Anwer
CPC分类号： C08G73/0206 , A61K47/34 , A61K48/00
摘要： A biodegradable cross-linked cationic multi-block copolymer of linear polyethylenimine (LPEI) wherein the LPEI blocks are linked together by hydrophilic linkers with a biodegradable disulfide bond and methods of making thereof. The biodegradable cross-linked cationic multi-block copolymer may also contain pendant functional moieties which are preferably receptor ligands, membrane permeating agents, endosomolytic agents, nuclear localization sequences, pH sensitive endosomolytic peptides, chromogenic or fluorescent dyes.
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