发明申请
US20090042964A1 AMINO-5-[SUBSTITUTED-4-(DIFLUOROMETHOXY)PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS AS BETA-SECRETASE INHIBITORS
审中-公开
氨基-5- [取代-4-（二氟甲基）苯基] -5-苯基咪唑烷酮化合物作为β-分泌酶抑制剂
![AMINO-5-[SUBSTITUTED-4-(DIFLUOROMETHOXY)PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS AS BETA-SECRETASE INHIBITORS](/docs/US/2009-02-12/US20090042964A1/abs.jpg.600x600.jpg)
- 专利标题： AMINO-5-[SUBSTITUTED-4-(DIFLUOROMETHOXY)PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS AS BETA-SECRETASE INHIBITORS
- 专利标题（中）： 氨基-5- [取代-4-（二氟甲基）苯基] -5-苯基咪唑烷酮化合物作为β-分泌酶抑制剂
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申请号： US12052098申请日： 2008-03-20
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公开(公告)号： US20090042964A1公开(公告)日： 2009-02-12
- 发明人: Michael Sotirios Malamas , Albert Jean Robichaud , Alexander Michael Porte , William R. Solvibile , Koi Michele Morris , Schuyler Adam Antane , Ji-In Kim , Robert Emmett McDevitt
- 申请人： Michael Sotirios Malamas , Albert Jean Robichaud , Alexander Michael Porte , William R. Solvibile , Koi Michele Morris , Schuyler Adam Antane , Ji-In Kim , Robert Emmett McDevitt
- 申请人地址： US NJ Madison
- 专利权人： Wyeth
- 当前专利权人： Wyeth
- 当前专利权人地址： US NJ Madison
- 主分类号： A61K31/4168
- IPC分类号： A61K31/4168 ; C07D233/32 ; A61P25/00
![AMINO-5-[SUBSTITUTED-4-(DIFLUOROMETHOXY)PHENYL]-5-PHENYLIMIDAZOLONE COMPOUNDS AS BETA-SECRETASE INHIBITORS](/abs-image/US/2009/02/12/US20090042964A1/abs.jpg.150x150.jpg)
摘要：
The present invention provides a 2-amino-5-[substituted-4-(difluoromethoxy)phenyl]-5-phenylimidazolone compound of formula I The present invention also provides methods for the use thereof to inhibit β-secretase (BACE) and treat β-amyloid deposits and neurofibrillary tangles.
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