发明申请
US20090048358A1 PLGA/Hydroxyapatite Composite Biomaterial and Method of Making the Same
审中-公开
PLGA /羟基磷灰石复合材料及其制备方法
- 专利标题: PLGA/Hydroxyapatite Composite Biomaterial and Method of Making the Same
- 专利标题(中): PLGA /羟基磷灰石复合材料及其制备方法
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申请号: US12279172申请日: 2007-03-06
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公开(公告)号: US20090048358A1公开(公告)日: 2009-02-19
- 发明人: Byung-Soo Kim
- 申请人: Byung-Soo Kim
- 申请人地址: US FL Boca Raton
- 专利权人: Nano Orthopedics, LLC
- 当前专利权人: Nano Orthopedics, LLC
- 当前专利权人地址: US FL Boca Raton
- 国际申请: PCT/US07/05693 WO 20070306
- 主分类号: A61F2/02
- IPC分类号: A61F2/02 ; C08J9/35 ; B29C43/00
摘要:
Tissue engineering is a growing field where new materials are being developed for implantation into the body. One important area involves bone graft materials to replace areas of bone lost to trauma or disease. Traditionally, graft material may be harvested from the bone of the individual receiving the graft material. However, this requires an additional surgery and additional recovery. Bone also may be taken from others, or even cadavers, but this introduces biocompatibility problems as well as the risk of disease transfer. Ideally, a biocompatible material is sought that will act as a filler with appropriate mechanical strength, encourage bone healing, and degrade to allow new bone ingrowth without the risk of disease transfer. The present invention is a new composite bone graft material made from biocompatible poly(D,L-lactic-co-glycolic acid) (PLGA) and nano-sized hydroxyapatite particles exposed on its surface using a gas foaming particle leaching (GF/PL) method. A further embodiment of this invention involves coating this PLGA/hydroxyapatite biomaterial with an adherent, fast, uniform coating of a mineral such as apatite. The PLGA polymer portion of the composite provides sufficient mechanical strength to replace bone and is degradable over time to allow new bone tissue ingrowth. The incorporated hydroxyapatite particles increase the composite material's osteogenic properties by providing sites for tissue attachment and propagation. Finally, a uniform coating of mineral apatite on the surface of this novel biomaterial composite further enhances its osteogenic qualities.
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