公开(公告)号：US08178013B2

公开(公告)日：2012-05-15

申请号：US11714507

申请日：2007-05-22

申请人： Byung-Soo Kim

发明人： Byung-Soo Kim

IPC分类号： B29C45/76 ,  B29C45/17 ,  B29C59/00 ,  D04H1/00 ,  C04B40/00 ,  B27N3/00

CPC分类号： A61L27/56 ,  A61L27/44 ,  A61L27/46 ,  A61L2400/12 ,  A61L2430/02 ,  C08L67/04

摘要： Tissue engineering is a growing field where new materials are being developed for implantation into the body. One important area involves bone graft materials to replace areas of bone lost to trauma or disease. Traditionally, graft material may be harvested from the bone of the individual receiving the graft material. However, this requires an additional surgery and additional recovery. Bone also may be taken from others, or even cadavers, but this introduces biocompatibility problems as well as the risk of disease transfer. Ideally, a biocompatible material is sought that will act as a filler with appropriate mechanical strength, encourage bone healing, and degrade to allow new bone ingrowth without the risk of disease transfer. The present invention is a new composite bone graft material made from biocompatible poly(D,L-lactic-co-glycolic acid) (PLGA) and nano-sized hydroxyapatite particles exposed on its surface using a gas foaming particle leaching (GF/PL) method. A further embodiment of this invention involves coating this PLGA/hydroxyapatite biomaterial with an adherent, fast, uniform coating of a mineral such as apatite. The PLGA polymer portion of the composite provides sufficient mechanical strength to replace bone and is degradable over time to allow new bone tissue ingrowth. The incorporated hydroxyapatite particles increase the composite material's osteogenic properties by providing sites for tissue attachment and propagation. Finally, a uniform coating of mineral apatite on the surface of this novel biomaterial composite further enhances its osteogenic qualities.

摘要翻译： 组织工程是一个不断发展的领域，新材料正在开发用于植入人体。 一个重要的领域涉及骨移植材料来代替创伤或疾病损失的骨骼部位。 传统上，可以从接受移植材料的个体的骨中收获移植材料。 然而，这需要额外的手术和额外的恢复。 骨头也可能来自其他人，甚至是尸体，但这会引起生物相容性问题以及疾病转移的风险。 理想地，寻求一种生物相容性材料，其将充当具有适当机械强度的填充物，促进骨骼愈合，并降解以允许新的骨向内生长而没有疾病转移的风险。 本发明是由生物相容性聚（D，L-乳酸 - 共 - 乙醇酸）（PLGA）和使用气泡发泡颗粒浸出（GF / PL）在其表面上暴露的纳米级羟基磷灰石颗粒制成的新型复合骨移植材料， 方法。 本发明的另一个实施方案涉及用粘附剂，快速均匀的矿物如磷灰石涂层来涂覆该PLGA /羟基磷灰石生物材料。 复合材料的PLGA聚合物部分提供了足够的机械强度来代替骨骼，并随着时间推移可降解，以允许新的骨组织向内生长。 掺入的羟基磷灰石颗粒通过提供用于组织附着和繁殖的位点增加复合材料的成骨性质。 最后，在这种新型生物材料复合材料表面上均匀地涂覆矿物磷灰石，进一步增强了其成骨质量。

公开(公告)号：US20090048358A1

公开(公告)日：2009-02-19

申请号：US12279172

申请日：2007-03-06

申请人： Byung-Soo Kim

发明人： Byung-Soo Kim

IPC分类号： A61F2/02 ,  C08J9/35 ,  B29C43/00

CPC分类号： A61L27/56 ,  A61L27/44 ,  A61L27/46 ,  A61L2400/12 ,  A61L2430/02 ,  C08L67/04

摘要： Tissue engineering is a growing field where new materials are being developed for implantation into the body. One important area involves bone graft materials to replace areas of bone lost to trauma or disease. Traditionally, graft material may be harvested from the bone of the individual receiving the graft material. However, this requires an additional surgery and additional recovery. Bone also may be taken from others, or even cadavers, but this introduces biocompatibility problems as well as the risk of disease transfer. Ideally, a biocompatible material is sought that will act as a filler with appropriate mechanical strength, encourage bone healing, and degrade to allow new bone ingrowth without the risk of disease transfer. The present invention is a new composite bone graft material made from biocompatible poly(D,L-lactic-co-glycolic acid) (PLGA) and nano-sized hydroxyapatite particles exposed on its surface using a gas foaming particle leaching (GF/PL) method. A further embodiment of this invention involves coating this PLGA/hydroxyapatite biomaterial with an adherent, fast, uniform coating of a mineral such as apatite. The PLGA polymer portion of the composite provides sufficient mechanical strength to replace bone and is degradable over time to allow new bone tissue ingrowth. The incorporated hydroxyapatite particles increase the composite material's osteogenic properties by providing sites for tissue attachment and propagation. Finally, a uniform coating of mineral apatite on the surface of this novel biomaterial composite further enhances its osteogenic qualities.

摘要翻译： 组织工程是一个不断发展的领域，新材料正在开发用于植入人体。 一个重要的领域涉及骨移植材料来代替创伤或疾病损失的骨骼部位。 传统上，可以从接受移植材料的个体的骨中收获移植材料。 然而，这需要额外的手术和额外的恢复。 骨头也可能来自其他人，甚至是尸体，但这会引起生物相容性问题以及疾病转移的风险。 理想地，寻求一种生物相容性材料，其将充当具有适当机械强度的填充物，促进骨骼愈合，并降解以允许新的骨向内生长而没有疾病转移的风险。 本发明是由生物相容性聚（D，L-乳酸 - 共 - 乙醇酸）（PLGA）和使用气泡发泡颗粒浸出（GF / PL）在其表面上暴露的纳米级羟基磷灰石颗粒制成的新型复合骨移植材料， 方法。 本发明的另一个实施方案涉及用粘附剂，快速均匀的矿物如磷灰石涂层来涂覆该PLGA /羟基磷灰石生物材料。 复合材料的PLGA聚合物部分提供了足够的机械强度来代替骨骼，并随着时间推移可降解，以允许新的骨组织向内生长。 掺入的羟基磷灰石颗粒通过提供用于组织附着和繁殖的位点增加复合材料的成骨性质。 最后，在这种新型生物材料复合材料表面上均匀地涂覆矿物磷灰石，进一步增强了其成骨质量。