发明申请
- 专利标题： Coagulation factor x polypeptides with modified activation properties
- 专利标题（中）： 凝血因子x多肽具有修饰的活化特性
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申请号： US11921399申请日： 2006-05-30
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公开(公告)号： US20090053185A1公开(公告)日： 2009-02-26
- 发明人: Stefan Schulte , Hans-Peter Hauser , Uwe Kalina , Thomas Weimer
- 申请人： Stefan Schulte , Hans-Peter Hauser , Uwe Kalina , Thomas Weimer
- 优先权： EP05011773.8 20050601
- 国际申请： PCT/EP2006/005131 WO 20060530
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C07K2/00 ; C07H21/04 ; C12N15/63 ; C12N5/00 ; C12P21/06 ; A61K38/00 ; A61K31/7088
摘要：
The present invention relates to modified cDNA sequences coding for human Factor X and their derivatives with improved stability and modified activation sequences, recombinant expression vectors containing such cDNA sequences, and host cells transformed with such recombinant expression vectors. The invention also relates to recombinant factor X polypeptides and derivatives which have biological activities of the unmodified wild type protein but with improved stability and processes for the manufacture of such recombinant proteins and their derivatives. The invention also covers a transfer vector for use in human gene therapy, which comprises such modified DNA.
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