发明申请
US20090053297A1 COMPOSITIONS AND METHODS FOR LESS IMMUNOGENIC PROTEIN-LIPID COMPLEXES
有权
组合物和方法用于较少免疫原性蛋白质 - 脂质复合物
- 专利标题： COMPOSITIONS AND METHODS FOR LESS IMMUNOGENIC PROTEIN-LIPID COMPLEXES
- 专利标题（中）： 组合物和方法用于较少免疫原性蛋白质 - 脂质复合物
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申请号： US12181178申请日： 2008-07-28
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公开(公告)号： US20090053297A1公开(公告)日： 2009-02-26
- 发明人: Sathy V. Balu-Iyer , Robert Straubinger , Karthik Ramani , Razvan D. Miclea
- 申请人： Sathy V. Balu-Iyer , Robert Straubinger , Karthik Ramani , Razvan D. Miclea
- 申请人地址： US NY Amherst
- 专利权人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
- 当前专利权人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
- 当前专利权人地址： US NY Amherst
- 主分类号： A61K9/127
- IPC分类号： A61K9/127 ; A61K31/74
摘要：
The present invention provides compositions and methods for reducing the immunogenicity and increasing the circulating half-life of therapeutic proteins such as Factor VIII. The compositions comprise lipidic structures such as liposomes, micelles and cochleates comprising a negatively charged lipid and polyethylene glycol derivatized phosphatidyl ethanolamine.
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