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1.发明授权公开(公告)号：US08110218B2
公开(公告)日：2012-02-07
申请号：US12181178
申请日：2008-07-28
CPC分类号： A61K9/1075 , A61K9/1271 , A61K9/1272 , A61K9/1274 , A61K31/74 , A61K38/37
摘要： The present invention provides compositions and methods for reducing the immunogenicity and increasing the circulating half-life of therapeutic proteins such as Factor VIII. The compositions comprise lipidic structures such as liposomes, micelles and cochleates comprising a negatively charged lipid and polyethylene glycol derivatized phosphatidyl ethanolamine.
摘要翻译： 本发明提供降低免疫原性并增加治疗性蛋白质如因子VIII的循环半衰期的组合物和方法。 组合物包含脂质体结构，例如包含带负电荷的脂质和聚乙二醇衍生的磷脂酰乙醇胺的脂质体，胶束和耳蜗。
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2.发明申请公开(公告)号：US20090053297A1
公开(公告)日：2009-02-26
申请号：US12181178
申请日：2008-07-28
CPC分类号： A61K9/1075 , A61K9/1271 , A61K9/1272 , A61K9/1274 , A61K31/74 , A61K38/37
摘要： The present invention provides compositions and methods for reducing the immunogenicity and increasing the circulating half-life of therapeutic proteins such as Factor VIII. The compositions comprise lipidic structures such as liposomes, micelles and cochleates comprising a negatively charged lipid and polyethylene glycol derivatized phosphatidyl ethanolamine.
摘要翻译： 本发明提供降低免疫原性并增加治疗性蛋白质如因子VIII的循环半衰期的组合物和方法。 组合物包含脂质体结构，例如包含带负电荷的脂质和聚乙二醇衍生的磷脂酰乙醇胺的脂质体，胶束和耳蜗。
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