发明申请
- 专利标题： PI3 kinase modulators and methods of use
- 专利标题（中）： PI3激酶调节剂和使用方法
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申请号： US12221416申请日： 2008-08-01
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公开(公告)号： US20090054405A1公开(公告)日： 2009-02-26
- 发明人: Shon Booker , Noel D'Angelo , Derin C. D'Amico , Tae-Seong Kim , Longbin Liu , Kristin Meagher , Mark H. Norman , Kathleen Panter , Laurie B. Schenkel , Adrian L. Smith , Nuria A. Tamayo , Douglas A. Whittington , Ning Xi , Kevin Yang
- 申请人： Shon Booker , Noel D'Angelo , Derin C. D'Amico , Tae-Seong Kim , Longbin Liu , Kristin Meagher , Mark H. Norman , Kathleen Panter , Laurie B. Schenkel , Adrian L. Smith , Nuria A. Tamayo , Douglas A. Whittington , Ning Xi , Kevin Yang
- 申请人地址： US CA Thousand Oaks
- 专利权人： Amgen Inc.
- 当前专利权人： Amgen Inc.
- 当前专利权人地址： US CA Thousand Oaks
- 主分类号： A61K31/55
- IPC分类号： A61K31/55 ; C07D401/14 ; C07D401/10 ; C07D413/14 ; A61P35/00 ; A61K31/435 ; A61K31/5377 ; A61K31/497
摘要：
The present invention comprises a new class of compounds capable of modulating the activity of PI3 kinase and, accordingly, useful for treatment of PI3 kinase mediated diseases, including melanomas, carcinomas and other cancer-related conditions. The compounds have a general Formula I wherein each of A1, A2, A3, A4, X, R1 and R2 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of PI3 kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.
公开/授权文献
- US07928140B2 Benzothiazole PI3 kinase modulators for cancer treatment 公开/授权日：2011-04-19
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