Invention Application
- Patent Title: PI3 kinase modulators and methods of use
- Patent Title (中): PI3激酶调节剂和使用方法
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Application No.: US12221416Application Date: 2008-08-01
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Publication No.: US20090054405A1Publication Date: 2009-02-26
- Inventor: Shon Booker , Noel D'Angelo , Derin C. D'Amico , Tae-Seong Kim , Longbin Liu , Kristin Meagher , Mark H. Norman , Kathleen Panter , Laurie B. Schenkel , Adrian L. Smith , Nuria A. Tamayo , Douglas A. Whittington , Ning Xi , Kevin Yang
- Applicant: Shon Booker , Noel D'Angelo , Derin C. D'Amico , Tae-Seong Kim , Longbin Liu , Kristin Meagher , Mark H. Norman , Kathleen Panter , Laurie B. Schenkel , Adrian L. Smith , Nuria A. Tamayo , Douglas A. Whittington , Ning Xi , Kevin Yang
- Applicant Address: US CA Thousand Oaks
- Assignee: Amgen Inc.
- Current Assignee: Amgen Inc.
- Current Assignee Address: US CA Thousand Oaks
- Main IPC: A61K31/55
- IPC: A61K31/55 ; C07D401/14 ; C07D401/10 ; C07D413/14 ; A61P35/00 ; A61K31/435 ; A61K31/5377 ; A61K31/497
Abstract:
The present invention comprises a new class of compounds capable of modulating the activity of PI3 kinase and, accordingly, useful for treatment of PI3 kinase mediated diseases, including melanomas, carcinomas and other cancer-related conditions. The compounds have a general Formula I wherein each of A1, A2, A3, A4, X, R1 and R2 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of PI3 kinase mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.
Public/Granted literature
- US07928140B2 Benzothiazole PI3 kinase modulators for cancer treatment Public/Granted day:2011-04-19
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