A computer implemented method, data processing system, and computer program product for generating and applying a model to predict hardware performance hazards in a machine instruction sequence. The illustrative embodiments generate rules which specify relationships between a first instruction code sequence and hardware performance hazards. This rule generation is performed as a machine task rather than a human task (e.g., traditional hand coding tools). When a second instruction code sequence is received, the rules are applied to the second instruction code sequence. Responsive to a prediction that execution of the second instruction code sequence will cause the hardware performance hazards, instructions in the second instruction code sequence that cause the hardware performance hazards are identified.