摘要:
A fusion protein having a non-immunoglobulin polypeptide having a cysteine residue proximal to the C terminal thereof, and an immunoglobulin component with a mutated hinge region is provided. The mutation comprises a point mutated site corresponding in position to the position in a native hinge region of the cysteine residue located nearest the cysteine residue of the non-Ig component. The distance from the cysteine residue of the non-immunoglobulin polypeptide and any remaining cysteine residues of the mutated hinge region is sufficient to prevent the formation of a disulphide bond therebetween.
摘要:
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
摘要:
The present invention discloses a method to operate phone using a single key, first provide method to form ‘key value’: (1) When the key is just closed, plus 1 to the ‘key value’, (2) When the key closing time is greater than time t1, form ‘closing key value’, (3) When the key closing time is smaller than t1 and the immediate key releasing time is greater than t2, store the key value as ‘releasing key value’, (4) When the key closing time is smaller than t1 and the immediate key releasing time is smaller than t2, skip to step (1). The ‘releasing key values’ can be used to represent the numerical and alphabetical keys on typical keypad of phone, while the ‘closing key values’ can be used to represent the function key on typical keypad of phone, so that the complete function of a typical phone keypad can be realized using only one key. Therefore, a phone can be made very small, which can be especially useful when installed on small Bluetooth device that connects to phone, since not only can it answer incoming phone calls, but also making outgoing phone calls.
摘要:
A pressure sensing device is disclosed in the present disclosure. The pressure sensing device includes a bottom plate, a flexible shell and a MEMS pressure sensor. The flexible shell covers the bottom plate for forming a hermetical cavity, and the MEMS pressure sensor is accommodated in the hermetical cavity. Air in the hermetical cavity is compressed when the flexible shell is pressed, the MEMS pressure sensor is configured for detecting variation of an air pressure within the hermetical cavity when the flexible shell is pressed, and convert the variation of the air pressure into an electric signal.
摘要:
Novel compounds of the structural formula (I), and the pharmaceutically acceptable salts thereof, are agonists of G-protein coupled receptor 40 (GPR40) and may be useful in the treatment, prevention and suppression of diseases mediated by the G-protein-coupled receptor 40. The compounds of the present invention may be useful in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
摘要:
The present invention provides a method for revamping an HF or sulphuric acid alkylation unit to an ionic liquid alkylation unit, wherein the HF or sulphuric acid alkylation unit comprise at least: —a reactor unit for contacting catalyst and hydrocarbon reactants; —a separator unit for separating a reactor effluent into a catalyst phase and an alkylate-comprising hydrocarbon phase; —a fractionator unit for fractionating the alkylate-comprising hydrocarbon phase into at least one stream comprising alkylate; —a catalyst phase recycle means to recycle at least part of the catalyst phase from the separator unit to the reactor unit; which method includes: —adapting the catalyst phase recycle means by providing a means for acid injection and/or a means for halohydrocarbon injection into the catalyst recycle means. The invention further provides a method for the production of alkylate.
摘要:
A method for making conductive wires is provided. Firstly, an ink having carbon nanotubes is provided. Secondly, a baseline is formed using the ink on a substrate. Thirdly, the baseline is electroless plated.
摘要:
Novel pyridine-2-carboxamide derivatives of formula I: and pharmaceutically acceptable salts thereof are disclosed as useful for treating or preventing type 2 diabetes and similar conditions. The compounds are effective as glucokinase activating agents. Pharmaceutical compositions and methods of treatment are also included.
摘要:
The present invention provides process for preparing an alkylate comprising contacting in a reaction zone a hydrocarbon mixture comprising at least an isoparaffin and an olefin with an acidic ionic liquid catalyst under alkylation conditions to obtain an alkylate-comprising effluent, in which process: —solids are formed in the reaction zone; —a solids-comprising effluent comprising hydrocarbons and acidic ionic liquid is withdrawn from the reaction zone; and—at least part of the solids-comprising effluent is treated to remove at least part of the solids to obtain a solids-depleted effluent. The invention further provides a process for treating an acidic ionic liquid comprising at least 0.1 wt % of solids based on the total weight of the acidic ionic liquid, wherein at least part of the solids are removed.
摘要:
A recommender system uses an activity decision tree to model the changes in a user's behavior according to a plurality of time-related features. The system determines historical activities for the user, and generates a decision tree for the user's historical activities. Each leaf node of the decision tree is associated with an activity-prediction model that computes a probability for a corresponding activity. The system selects a path of the decision tree from a root node to a leaf node of the decision tree based on a target time. The selected path traverses two or more non-leaf nodes that are each associated with a temporal decision model that compares the target time against a temporal classifier. The system then determines a probability for a user activity based on an activity-prediction model of the selected path.