发明申请
US20090060930A1 Enhanced immunogenicity of tumor associated antigens by addition of alphaGal epitopes
有权
通过添加αGal表位增强肿瘤相关抗原的免疫原性
- 专利标题: Enhanced immunogenicity of tumor associated antigens by addition of alphaGal epitopes
- 专利标题(中): 通过添加αGal表位增强肿瘤相关抗原的免疫原性
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申请号: US11977203申请日: 2007-10-24
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公开(公告)号: US20090060930A1公开(公告)日: 2009-03-05
- 发明人: Mario R. Mautino , Nicholas N. Vahanian , Won-Bin Young , Gabriela Rossi , Charles J. Link , Firoz Jaipuri
- 申请人: Mario R. Mautino , Nicholas N. Vahanian , Won-Bin Young , Gabriela Rossi , Charles J. Link , Firoz Jaipuri
- 专利权人: NEWLINK GENETICS
- 当前专利权人: NEWLINK GENETICS
- 主分类号: A61K39/385
- IPC分类号: A61K39/385 ; C12P21/06 ; C07K4/00 ; C07K14/00 ; C07C229/00 ; C07H3/02 ; C07H3/04 ; C07H3/06
摘要:
The invention relates to methods and compositions for causing the selective targeting and killing of tumor cells. The present invention describes prophylactic or therapeutic cancer vaccines based on purified TAA proteins or TAA-derived synthetic peptides altered by chemical, enzymatic or chemo-enzymatic methods to introduce αGal epitopes or αGal glycomimetic epitopes, in order to allow for enhanced opsonization of the antigen by natural anti-αGal antibodies to stimulate TAA capture and presentation, thereby inducing a humoral and cellular immune response to the TAA expressed by a tumor. The animal's immune system thus is stimulated to produce tumor specific cytotoxic cells and antibodies which will attack and kill tumor cells present in the animal.