发明申请
US20090069419A1 MASKED CARBOXYLATE NEOPENTYL SULFONYL ESTER CYCLIZATION RELEASE PRODRUGS OF ACAMPROSATE, COMPOSITIONS THEREOF, AND METHODS OF USE
审中-公开
掩蔽的羧酸酯类抗坏血酸酯环氧化合物释放丙酸钠，其组合物及其使用方法
- 专利标题： MASKED CARBOXYLATE NEOPENTYL SULFONYL ESTER CYCLIZATION RELEASE PRODRUGS OF ACAMPROSATE, COMPOSITIONS THEREOF, AND METHODS OF USE
- 专利标题（中）： 掩蔽的羧酸酯类抗坏血酸酯环氧化合物释放丙酸钠，其组合物及其使用方法
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申请号： US12204961申请日： 2008-09-05
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公开(公告)号： US20090069419A1公开(公告)日： 2009-03-12
- 发明人: Bernd Jandeleit , Yunxiao Li , Mark A. Gallop , Noa Zerangue , Peter A. Virsik , Wolf-Nicolas Fischer
- 申请人： Bernd Jandeleit , Yunxiao Li , Mark A. Gallop , Noa Zerangue , Peter A. Virsik , Wolf-Nicolas Fischer
- 主分类号： A61K31/255
- IPC分类号： A61K31/255 ; C07C233/01 ; A61K31/164 ; A61P25/28 ; A61P25/22 ; A61P25/18 ; C07C303/02
摘要：
Masked carboxylate neopentyl sulfonyl ester prodrugs of acamprosate, pharmaceutical compositions comprising such prodrugs, and methods of using such prodrugs and compositions thereof for treating diseases are disclosed. In particular, acamprosate prodrugs exhibiting enhanced oral bioavailability and methods of using acamprosate prodrugs to treat neurodegenerative disorders, psychotic disorders, mood disorders, anxiety disorders, somatoform disorders, movement disorders, substance abuse disorders, binge eating disorder, cortical spreading depression related disorders, tinnitus, sleeping disorders, multiple sclerosis, and pain are disclosed.
公开/授权文献
- US3096003A Aerosol valve permitting fast injection 公开/授权日：1963-07-02
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