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    Simple pantoic acid ester neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use
    2.
    发明授权
    Simple pantoic acid ester neopentyl sulfonyl ester cyclization release prodrugs of acamprosate, compositions thereof, and methods of use 失效
    简单的泛酸酯新戊酰磺酰酯环化释放前药，其组合物和使用方法

    公开(公告)号：US07994218B2

    公开(公告)日：2011-08-09

    申请号：US12205080

    申请日：2008-09-05

    申请人： Bernd Jandeleit ,  Yunxiao Li ,  Mark A. Gallop ,  Noa Zerangue ,  Peter A. Virsik ,  Wolf-Nicolas Fischer

    发明人： Bernd Jandeleit ,  Yunxiao Li ,  Mark A. Gallop ,  Noa Zerangue ,  Peter A. Virsik ,  Wolf-Nicolas Fischer

    IPC分类号： A61K31/255 ,  C07C307/02

    CPC分类号： C07C309/15

    摘要： Pantoic acid ester neopentyl sulfonyl ester prodrugs of acamprosate, pharmaceutical compositions comprising such prodrugs, and methods of using such prodrugs and compositions thereof for treating diseases are disclosed. In particular, acamprosate prodrugs exhibiting enhanced oral bioavailability and methods of using acamprosate prodrugs to treat neurodegenerative disorders, psychotic disorders, mood disorders, anxiety disorders, somatoform disorders, movement disorders, substance abuse disorders, binge eating disorder, cortical spreading depression related disorders, tinnitus, sleeping disorders, multiple sclerosis, and pain are disclosed.

    摘要翻译： 公开了阿卡波酸的泛酸酯新戊基磺酰酯前药，包含这些前药的药物组合物，以及使用这些前药及其组合物治疗疾病的方法。 特别地，表现出增强的口服生物利用度的阿坎酸酯前药和使用阿坎酸类前药治疗神经变性疾病，精神病性障碍，情绪障碍，焦虑症，躯体形式障碍，运动障碍，物质滥用障碍，暴饮暴食症，皮质扩张抑郁症相关疾病，耳鸣的方法 ，睡眠障碍，多发性硬化和疼痛。

    EXTERNALLY MASKED NEOPENTYL SULFONYL ESTER CYCLIZATION RELEASE PRODRUGS OF ACAMPROSATE, COMPOSITIONS THEREOF, AND METHODS OF USE
    7.
    发明申请
    EXTERNALLY MASKED NEOPENTYL SULFONYL ESTER CYCLIZATION RELEASE PRODRUGS OF ACAMPROSATE, COMPOSITIONS THEREOF, AND METHODS OF USE 审中-公开
    外用苯丙醇磺酸酯环化酶释放丙酸钠，其组合物及其使用方法

    公开(公告)号：US20090082464A1

    公开(公告)日：2009-03-26

    申请号：US12205275

    申请日：2008-09-05

    申请人： Bernd Jandeleit ,  Yunxiao Li ,  Mark A. Gallop ,  Noa Zerangue ,  Peter A. Virsik ,  Wolf-Nicolas Fischer

    发明人： Bernd Jandeleit ,  Yunxiao Li ,  Mark A. Gallop ,  Noa Zerangue ,  Peter A. Virsik ,  Wolf-Nicolas Fischer

    IPC分类号： A61K31/16 ,  C07C233/00

    CPC分类号： C07C309/15

    摘要： Masked nitrogen-substituted and oxygen-substituted neopentyl sulfonyl ester prodrugs of acamprosate, pharmaceutical compositions comprising such prodrugs, and methods of using such prodrugs and compositions thereof for treating diseases are disclosed. In particular, acamprosate prodrugs exhibiting enhanced oral bioavailability and methods of using acamprosate prodrugs to treat neurodegenerative disorders, psychotic disorders, mood disorders, anxiety disorders, somatoform disorders, movement disorders, substance abuse disorders, binge eating disorder, cortical spreading depression related disorders, tinnitus, sleeping disorders, multiple sclerosis, and pain are disclosed.

    摘要翻译： 本发明公开了阿卡波酸的掩蔽的氮取代和氧取代的新戊基磺酰酯前药，包含这些前药的药物组合物，以及使用这些前药及其组合物治疗疾病的方法。 特别地，表现出增强的口服生物利用度的阿坎酸酯前药和使用阿坎酸类前药治疗神经变性疾病，精神病性障碍，情绪障碍，焦虑症，躯体形式障碍，运动障碍，物质滥用障碍，暴饮暴食症，皮质扩张抑郁症相关疾病，耳鸣的方法 ，睡眠障碍，多发性硬化和疼痛。