发明申请
- 专利标题: MACROLIDE DERIVATIVES
- 专利标题(中): 麦角糖衍生物
-
申请号: US12299229申请日: 2007-05-01
-
公开(公告)号: US20090076253A1公开(公告)日: 2009-03-19
- 发明人: Masato Kashimura , Madoka Kawamura , Toshifumi Asaka , Kiyoshi Takayama , Haruhisa Ogita
- 申请人: Masato Kashimura , Madoka Kawamura , Toshifumi Asaka , Kiyoshi Takayama , Haruhisa Ogita
- 申请人地址: JP Toshima-ku, Tokyo
- 专利权人: TAISHO PHARMACEUTICAL CO., LTD
- 当前专利权人: TAISHO PHARMACEUTICAL CO., LTD
- 当前专利权人地址: JP Toshima-ku, Tokyo
- 优先权: JP2006-127277 20060501; JP2007-000881 20070106
- 国际申请: PCT/JP2007/059327 WO 20070501
- 主分类号: C07H17/08
- IPC分类号: C07H17/08
摘要:
Compounds represented by formula (I) and the formula (IV) have an inhibitory activity of MMP-9 production, therefore, are useful as a medicine agent with fewer side effects than conventional MMP enzyme activity inhibitors, as a prophylactic and therapeutic drug for oncogenic angiogenesis, chronic rheumatoid arthritis, vascular intimal thickening after a percutaneous coronary transluminal angioplasty, vascular atherosclerosis, hemorrhagic apoplexy, acute myocardial infarction, chronic heart failure, aneurysm, lung cancer metastasis, adult respiratory distress syndrome, asthma, interstitial pulmonary fibrosis, chronic rhinosinusitis, bronchitis or chronic obstructive pulmonary disease (COPD).
公开/授权文献
- US08124744B2 Macrolide derivatives 公开/授权日:2012-02-28