发明申请
- 专利标题： MODIFIED HEPARINASE III AND METHODS OF SEQUENCING THEREWITH
- 专利标题（中）： 修饰的蛋白酶III及其序列的方法
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申请号： US12261004申请日： 2008-10-29
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公开(公告)号： US20090081635A1公开(公告)日： 2009-03-26
- 发明人: DONGFANG LIU , Kevin Pojasek , Zachary Shriver , Kristine Holley , Yosuf El-Shabrawi , Ganesh Venkataraman , Ram Sasisekharan
- 申请人： DONGFANG LIU , Kevin Pojasek , Zachary Shriver , Kristine Holley , Yosuf El-Shabrawi , Ganesh Venkataraman , Ram Sasisekharan
- 申请人地址： US MA Cambridge
- 专利权人： Massachusetts Institute of Technology
- 当前专利权人： Massachusetts Institute of Technology
- 当前专利权人地址： US MA Cambridge
- 主分类号： C12Q1/00
- IPC分类号： C12Q1/00
摘要：
The invention relates to heparinase III and mutants thereof. Modified forms of heparinase III having reduced enzymatic activity which are useful for a variety of purposes, including sequencing of heparin-like glycosaminoglycans (HLGAGs), removing active heparan sulfate from a solution, inhibition of angiogenesis, etc. have been discovered according to the invention. The invention in other aspects relates to methods of treating cancer and inhibiting tumor cell growth and/or metastasis using heparinase III, or products produced by enzymatic cleavage by heparinase III of HLGAGs.
公开/授权文献
- US07939292B2 Modified heparinase III and methods of sequencing therewith 公开/授权日：2011-05-10
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