- 专利标题: IMMUNE REGULATORY OLIGONUCLEOTIDE (IRO) COMPOUNDS TO MODULATE TOLL-LIKE RECEPTOR BASED IMMUNE RESPONSE
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申请号: US12140334申请日: 2008-06-17
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公开(公告)号: US20090087388A1公开(公告)日: 2009-04-02
- 发明人: Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
- 申请人: Ekambar Kandimalla , Daqing Wang , Yukui Li , Dong Yu , FuGang Zhu , Lakshmi Bhagat , Sudhir Agrawal
- 专利权人: Idera Pharmaceuticals, Inc.
- 当前专利权人: Idera Pharmaceuticals, Inc.
- 主分类号: A61K9/12
- IPC分类号: A61K9/12 ; A61K31/7088 ; A61K39/00 ; A61K39/395 ; A61K8/49 ; A61K38/00 ; A61K39/35
摘要:
The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.