发明申请
- 专利标题： Protein secretion in eukaryotic cells
- 专利标题（中）： 蛋白质分泌在真核细胞中
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申请号： US12231168申请日： 2008-08-28
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公开(公告)号： US20090087882A1公开(公告)日： 2009-04-02
- 发明人: Roland Contreras , Steven Geysens
- 申请人： Roland Contreras , Steven Geysens
- 专利权人： Vlaams Interuniversitar Instituut Voor Biotechnologie VZW,Universiteit Gent
- 当前专利权人： Vlaams Interuniversitar Instituut Voor Biotechnologie VZW,Universiteit Gent
- 优先权： EP03075728.0 20030312
- 主分类号： C12P21/04
- IPC分类号： C12P21/04 ; C12N1/19
摘要：
The invention relates to the use of a glucosidase II mutation to increase protein secretion in yeast cells. The invention relates further to the use of yeast cells, comprising a mutant glucosidase II gene, possibly in combination with the expression of a recombinant α-1,2-mannosidase gene and/or a recombinant N-acetylglucosaminyl-transferase gene, as a host for protein secretion.
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