发明申请
US20090088428A1 CYCLOHEXYLIMIDIAZOLE LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1
有权
作为11-羟基脱氢酶脱氢酶1的抑制剂的环己基咪唑啉酮衍生物
- 专利标题： CYCLOHEXYLIMIDIAZOLE LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1
- 专利标题（中）： 作为11-羟基脱氢酶脱氢酶1的抑制剂的环己基咪唑啉酮衍生物
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申请号： US12297361申请日： 2007-04-19
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公开(公告)号： US20090088428A1公开(公告)日： 2009-04-02
- 发明人: Ashraf Saeed , Owen Brendan Wallace , Yanping Xu , Thomas Edward Mabry , Rebecca Lynn Rezac Guenther , Nancy June Snyder
- 申请人： Ashraf Saeed , Owen Brendan Wallace , Yanping Xu , Thomas Edward Mabry , Rebecca Lynn Rezac Guenther , Nancy June Snyder
- 国际申请： PCT/US07/66907 WO 20070419
- 主分类号： A61K31/4184
- IPC分类号： A61K31/4184 ; C07D403/02 ; C07D405/14 ; C07D413/14 ; C07D401/14 ; C07D403/14 ; A61K31/5377 ; A61K31/496 ; A61K31/454 ; A61K31/506 ; A61K31/437 ; A61P3/10
摘要：
The present invention discloses novel compounds of Formula I: (I) having 11β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11β-HSD type 1 activity.
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