发明申请
US20090088430A1 PIERIDINYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1
失效
作为11-羟基脱氢酶脱氢酶1的抑制剂的狄氏剂替代吡咯烷酮
- 专利标题： PIERIDINYL SUBSTITUTED PYRROLIDINONES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1
- 专利标题（中）： 作为11-羟基脱氢酶脱氢酶1的抑制剂的狄氏剂替代吡咯烷酮
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申请号： US12297951申请日： 2007-04-27
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公开(公告)号： US20090088430A1公开(公告)日： 2009-04-02
- 发明人: Owen Brendan Wallace , Yanping Xu , Jeremy Schulenburg York
- 申请人： Owen Brendan Wallace , Yanping Xu , Jeremy Schulenburg York
- 国际申请： PCT/US07/67597 WO 20070427
- 主分类号： A61K31/454
- IPC分类号： A61K31/454 ; C07D401/04 ; C07D401/14 ; C07D413/14 ; A61P3/10 ; A61K31/5377 ; A61K31/496 ; A61K31/4545
摘要：
The present invention discloses novel compounds of Formula I: having 11β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11β-HSD type 1 activity.
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