Apparatus, systems, and devices are described that utilize an adjustable biological tissue cutting handpiece that is based on selectable settings. The biological tissue cutting handpiece includes a cutter tip that allows multiple duty cycles as well as multiple port configurations. For example, when working next to the retina, the port could be adjusted to be a smaller size, allowing delicate membrane dissection. When working near or in less sensitive tissue, e.g. the center of the eye, the port could be wide open. The port aperture size can be independent of cut speed, allowing a surgeon to work at high speed both next to the retina and away from the retina. High speeds have been shown to have increased tissue (e.g., vitreous) removal, e.g., in 25 and 23-gauge instruments. Duty cycle is not necessarily dependent on cut speed, allowing high cutter performance and varied flow characteristics.