发明申请
- 专利标题： Cell lines and animal models of HER2 expressing tumors
- 专利标题（中）： HER2表达肿瘤的细胞系和动物模型
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申请号： US11875251申请日： 2007-10-19
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公开(公告)号： US20090098115A1公开(公告)日： 2009-04-16
- 发明人: Lisa Michele Crocker , Sarajane Ross , Gail Dianne Phillips
- 申请人： Lisa Michele Crocker , Sarajane Ross , Gail Dianne Phillips
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C12N5/06 ; A01K67/027 ; A61K38/02 ; C12Q1/02
摘要：
The present invention concerns cell lines and animal models of HER2-expressing tumors. In particular, the invention concerns cell lines and animal models of HER2-expressing tumors not responding or responding poorly to treatment with trastuzumab (HERCEPTIN®, Genentech, Inc.). The animal models and cell lines of the invention are useful for evaluating the efficacy of various therapeutic approaches for the treatment of such tumors.
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