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1.发明申请COMPOSITIONS AND METHODS FOR THE TREATMENT OF TUMOR OF HEMATOPOIETIC ORIGIN 审中-公开用于治疗HEMATOPOIETIC ORIGIN肿瘤的组合物和方法公开(公告)号：US20070207142A1
公开(公告)日：2007-09-06
申请号：US11462336
申请日：2006-08-03
申请人： Craig Crowley , Frederic de Sauvage , Dan Eaton , Allen Ebens , Jo-Anne Hongo , Andrew Polson , Sarajane Ross , Victoria Smith , Richard Vandlen
发明人： Craig Crowley , Frederic de Sauvage , Dan Eaton , Allen Ebens , Jo-Anne Hongo , Andrew Polson , Sarajane Ross , Victoria Smith , Richard Vandlen
IPC分类号： A61K39/44 , A61J1/00 , C07H21/04 , C07K16/00 , C12N1/16 , C12N15/63 , G01N33/574 , C12P21/02 , C12N1/20 , C07K16/18 , C07K14/00 , A61K38/00
CPC分类号： C07K14/705 , A61K38/00 , A61K2039/505 , C07K16/30 , C07K16/3061 , C07K2317/73 , C07K2317/77 , G01N33/574
摘要： The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
摘要翻译： 本发明涉及可用于治疗哺乳动物造血肿瘤的物质组合物，以及使用这些物质组合物的方法。
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公开(公告)号：US20110206658A1
公开(公告)日：2011-08-25
申请号：US12902434
申请日：2010-10-12
申请人： Craig Crowley , Frederic J. de Sauvage , Dan L. Eaton , Allen Ebens, JR. , Kristi Elkins , Jo-Anne S. Hongo , Jagath Reddy Juntula , Andrew Polson , Sarajane Ross , Victoria Smith , Richard L. Vandlen , Bing Zheng
发明人： Craig Crowley , Frederic J. de Sauvage , Dan L. Eaton , Allen Ebens, JR. , Kristi Elkins , Jo-Anne S. Hongo , Jagath Reddy Juntula , Andrew Polson , Sarajane Ross , Victoria Smith , Richard L. Vandlen , Bing Zheng
IPC分类号： A61K39/395 , C07K16/44 , G01N33/53 , G01N33/574 , C12N5/02 , A61P35/00
CPC分类号： C07K16/2803 , A61K38/00 , A61K47/6817 , A61K47/6851 , A61K2039/505 , C07K14/705 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/624 , C07K2317/73 , C07K2317/77 , C07K2317/92 , G01N33/574
摘要： The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
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公开(公告)号：US20110042260A1
公开(公告)日：2011-02-24
申请号：US12855625
申请日：2010-08-12
申请人： Craig Crowley , Frederic J. de Sauvage , Dan L. Eaton , Allen Ebens, JR. , Jo-Anne S. Hongo , Andrew Polson , Sarajane Ross , Victoria Smith , Richard L. Vandlen
发明人： Craig Crowley , Frederic J. de Sauvage , Dan L. Eaton , Allen Ebens, JR. , Jo-Anne S. Hongo , Andrew Polson , Sarajane Ross , Victoria Smith , Richard L. Vandlen
IPC分类号： B65D85/84 , C07K16/00 , A61K39/395 , A61P35/00 , C12Q1/02
CPC分类号： C07K14/705 , A61K38/00 , C07K16/30 , C07K2317/34 , C07K2317/77 , G01N33/574
摘要： The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
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4.发明申请COMPOSITIONS AND METHODS FOR THE TREATMENT OF TUMOR OF HEMATOPOIETIC 审中-公开用于治疗HEMATOPOIETIC肿瘤的组合物和方法公开(公告)号：US20110070243A1
公开(公告)日：2011-03-24
申请号：US12878920
申请日：2010-09-09
申请人： CRAIG CROWLEY , FREDERIC J. DE SAUVAGE , DAN L. EATON , ALLEN EBENS, JR. , KRISTI ELKINS , JO-ANNE S. HONGO , JAGATH REDDY JUNUTULA , ANDREW POLSON , SARAJANE ROSS , VICTORIA SMITH , RICHARD L. VANDLEN , BING ZHENG
发明人： CRAIG CROWLEY , FREDERIC J. DE SAUVAGE , DAN L. EATON , ALLEN EBENS, JR. , KRISTI ELKINS , JO-ANNE S. HONGO , JAGATH REDDY JUNUTULA , ANDREW POLSON , SARAJANE ROSS , VICTORIA SMITH , RICHARD L. VANDLEN , BING ZHENG
CPC分类号： C07K16/2803 , A61K38/00 , A61K47/6817 , A61K47/6851 , A61K2039/505 , C07K14/705 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/624 , C07K2317/73 , C07K2317/77 , C07K2317/92 , G01N33/574
摘要： The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
摘要翻译： 本发明涉及可用于治疗哺乳动物造血肿瘤的物质组合物，以及使用这些物质组合物的方法。
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公开(公告)号：US20060212956A1
公开(公告)日：2006-09-21
申请号：US11375153
申请日：2006-03-13
申请人： Lisa Crocker , Sarajane Ross , Gail Phillips
发明人： Lisa Crocker , Sarajane Ross , Gail Phillips
IPC分类号： A01K67/027 , C12Q1/68 , G01N33/574 , C12N5/06
CPC分类号： C12N5/0693 , A01K2267/0331 , C12N2503/02 , G01N33/5011 , G01N33/57415
摘要： The invention concerns animal models of ligand activated HER2-expressing tumors. This model is useful for evaluating the efficacy of various therapeutic approaches for the treatment of such tumors.
摘要翻译： 本发明涉及配体活化的表达HER2的肿瘤的动物模型。 该模型可用于评估各种治疗方法治疗这种肿瘤的功效。
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公开(公告)号：US06689744B2
公开(公告)日：2004-02-10
申请号：US09954736
申请日：2001-09-17
申请人： Wei-Qiang Gao , Hartmut Koeppen , Sarajane Ross , Jianyong Shou
发明人： Wei-Qiang Gao , Hartmut Koeppen , Sarajane Ross , Jianyong Shou
IPC分类号： A61K3800
CPC分类号： A61K38/1709 , A61K2039/505 , G01N33/57434 , G01N2500/00
摘要： The present invention is directed to methods of alleviating prostate disorders by activation of the Notch1 receptor. Also provided herein are methods for detecting and diagnosing prostate disorders, wherein the specific disorder is prostate cancer.
摘要翻译： 本发明涉及通过Notch1受体活化来减轻前列腺障碍的方法。 本文还提供了用于检测和诊断前列腺疾病的方法，其中特异性病症是前列腺癌。
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公开(公告)号：US20090098115A1
公开(公告)日：2009-04-16
申请号：US11875251
申请日：2007-10-19
IPC分类号： A61K39/395 , C12N5/06 , A01K67/027 , A61K38/02 , C12Q1/02
CPC分类号： A01K67/0271 , A01K2217/15 , A01K2227/105 , A01K2267/0331 , A61K31/565 , A61K39/39558 , A61K45/06 , A61K47/6803 , A61K47/6855 , A61K2039/505 , A61K2039/545 , C07K16/32 , G01N33/5011 , A61K2300/00
摘要： The present invention concerns cell lines and animal models of HER2-expressing tumors. In particular, the invention concerns cell lines and animal models of HER2-expressing tumors not responding or responding poorly to treatment with trastuzumab (HERCEPTIN®, Genentech, Inc.). The animal models and cell lines of the invention are useful for evaluating the efficacy of various therapeutic approaches for the treatment of such tumors.
摘要翻译： 本发明涉及表达HER2的肿瘤的细胞系和动物模型。 特别地，本发明涉及对曲妥珠单抗（Genentech，Inc。）治疗无反应或反应不良的HER2表达肿瘤的细胞系和动物模型。 本发明的动物模型和细胞系可用于评估用于治疗这种肿瘤的各种治疗方法的功效。
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8.发明申请公开(公告)号：US20090068178A1
公开(公告)日：2009-03-12
申请号：US12023811
申请日：2008-01-31
申请人： Craig Crowley , Frederic J. de Sauvage , Dan L. Eaton , Allen Ebens, JR. , Kristi Elkins , Jo-Anne S. Hongo , Jagath Reddy Junutula , Andrew Polson , Sarajane Ross , Victoria Smith , Richard L. Vandlen , Bing Zheng
发明人： Craig Crowley , Frederic J. de Sauvage , Dan L. Eaton , Allen Ebens, JR. , Kristi Elkins , Jo-Anne S. Hongo , Jagath Reddy Junutula , Andrew Polson , Sarajane Ross , Victoria Smith , Richard L. Vandlen , Bing Zheng
IPC分类号： A61K39/395 , C07H21/04 , C12N15/63 , C12N5/10 , C12N1/21 , C12N1/19 , C12P21/06 , C12N9/96 , A61K39/44 , C12Q1/68 , A61K31/7088 , G01N33/574 , C12N5/08 , C12N5/02 , C07K14/00 , C07K16/00 , A61P35/04 , C12P21/08 , A61K38/16
CPC分类号： C07K16/2803 , A61K38/00 , A61K47/6817 , A61K47/6851 , A61K2039/505 , C07K14/705 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/624 , C07K2317/73 , C07K2317/77 , C07K2317/92 , G01N33/574
摘要： The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.
摘要翻译： 本发明涉及可用于治疗哺乳动物造血肿瘤的物质组合物，以及使用这些物质组合物的方法。
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