发明申请
US20090105139A1 Soluble HER2 and HER3 splice variant proteins, splice-switching oligonucleotides, and their use in the treatment of disease
有权
可溶性HER2和HER3剪接变体蛋白，剪接切换寡核苷酸及其在治疗疾病中的应用
- 专利标题： Soluble HER2 and HER3 splice variant proteins, splice-switching oligonucleotides, and their use in the treatment of disease
- 专利标题（中）： 可溶性HER2和HER3剪接变体蛋白，剪接切换寡核苷酸及其在治疗疾病中的应用
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申请号： US12157094申请日： 2008-06-06
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公开(公告)号： US20090105139A1公开(公告)日： 2009-04-23
- 发明人: Ryszard Kole , Peter Sazani , Jing Wan
- 申请人： Ryszard Kole , Peter Sazani , Jing Wan
- 申请人地址： US OR Corvallis
- 专利权人： AVI BioPharma, Inc.
- 当前专利权人： AVI BioPharma, Inc.
- 当前专利权人地址： US OR Corvallis
- 主分类号： A61K38/16
- IPC分类号： A61K38/16 ; C07K14/00 ; A61K31/7088 ; A61K31/7105 ; C12N15/11
摘要：
Soluble epidermal growth factor receptors 2 and 3 (HER2 and HER3) splice variant proteins with HER2 and HER3 antagonist activity and anti-proliferative properties, as well as the corresponding nucleic acids, are provided for treatment of proliferative diseases, in particular cancer. Also provided are compositions and methods for inducing expression of these splice variants, including splice switching oligonucleotides that modulate splicing of pre-mRNA that codes for these receptors.
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