发明申请
US20090110684A1 Neutralizing monoclonal antibodies to respiratory syncytial virus
审中-公开
呼吸道合胞病毒的中和单克隆抗体
- 专利标题: Neutralizing monoclonal antibodies to respiratory syncytial virus
- 专利标题(中): 呼吸道合胞病毒的中和单克隆抗体
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申请号: US12082000申请日: 2008-04-24
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公开(公告)号: US20090110684A1公开(公告)日: 2009-04-30
- 发明人: Glenn R. Pilkington , Page S. Gilmour , Robert M. Chanock , James E. Crowe, JR. , Brian R. Murphy
- 申请人: Glenn R. Pilkington , Page S. Gilmour , Robert M. Chanock , James E. Crowe, JR. , Brian R. Murphy
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; A61K31/7088 ; A61P31/12
摘要:
The present invention relates to the identification and cloning of a novel neutralizing human monoclonal antibody to the Respiratory Syncytial Virus. The invention provides such antibodies, fragments of such antibodies retaining RSV-binding ability, chimeric antibodies retaining RSV-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Finally, the invention provides for diagnostic and therapeutic methods employing the antibodies and nucleic acids of the invention.
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