发明申请
US20090111807A1 Novel 1,2,3,4-Tetrahydroquinoxaline Derivative Having Glucocorticoid Receptor Binding Activity
有权
具有糖皮质激素受体结合活性的新型1,2,3,4-四氢喹喔啉衍生物
- 专利标题: Novel 1,2,3,4-Tetrahydroquinoxaline Derivative Having Glucocorticoid Receptor Binding Activity
- 专利标题(中): 具有糖皮质激素受体结合活性的新型1,2,3,4-四氢喹喔啉衍生物
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申请号: US12225010申请日: 2007-03-14
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公开(公告)号: US20090111807A1公开(公告)日: 2009-04-30
- 发明人: Mamoru Matsuda , Toshiyuki Mori , Kenji Kawashima , Minoru Yamamoto , Masatomo Kato , Miwa Takai , Masato Nagatsuka , Sachiko Kobayashi
- 申请人: Mamoru Matsuda , Toshiyuki Mori , Kenji Kawashima , Minoru Yamamoto , Masatomo Kato , Miwa Takai , Masato Nagatsuka , Sachiko Kobayashi
- 申请人地址: JP Osaka
- 专利权人: SANTEN PHARMACEUTICAL CO., LTD.
- 当前专利权人: SANTEN PHARMACEUTICAL CO., LTD.
- 当前专利权人地址: JP Osaka
- 优先权: JP2006-069739 20060314; JP2006-255039 20060822
- 国际申请: PCT/JP2007/055122 WO 20070314
- 主分类号: C07D241/36
- IPC分类号: C07D241/36 ; A61K31/498 ; A61K31/5377 ; C07D413/10 ; A61P37/00 ; A61P37/08 ; A61P9/00 ; A61P3/00
摘要:
An object of the present invention is to synthesize a novel 1,2,3,4-tetrahydroquinoxaline derivative represented by formula (1) and to find a pharmacological action of the derivative. In the formula, the R1 represents a halogen, an alkyl, cycloalkyl, aryl or heterocyclic group, or the like; p represents 0 to 5; R2 represents a halogen, an alkyl, hydroxyl or alkoxy group, or the like; q represents 0 to 2; R3 represents hydrogen, an alkyl, alkenyl, alkylcarbonyl or arylcarbonyl group, or the like; R4 and R5 independently represent hydrogen, a halogen, an alkyl, alkenyl, alkynyl, cycloalkyl, aryl or heterocyclic group, or the like; R6 represents hydrogen, an alkyl, alkenyl, alkynyl, cycloalkyl, aryl or heterocyclic group, or the like; A represents an alkylene; R7 represents OR8, NR8R9, SR8, S(O)R8, S(O)2R8; and X represents O or S.
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