发明申请
US20090123372A1 DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY
有权
使用单一化学物质开发碳氢化合物IX的分子成像探针
- 专利标题： DEVELOPMENT OF MOLECULAR IMAGING PROBES FOR CARBONIC ANHYDRASE-IX USING CLICK CHEMISTRY
- 专利标题（中）： 使用单一化学物质开发碳氢化合物IX的分子成像探针
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申请号： US12099135申请日： 2008-04-07
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公开(公告)号： US20090123372A1公开(公告)日： 2009-05-14
- 发明人: Hartmuth C. Kolb , Joseph C. Walsh , Dhanalakshmi Kasi , Vani P. Mocharla , Bing Wang , Umesh B. Gangadharmath , Brian A. Duclos , Kai Chen , Wei Zhang , Gang Chen , Henry Clifton Padgett , Farhad Karimi , Peter J. H. Scott , Zhiyong Gao , Qianwa Liang , Thomas Lee Collier , Tieming Zhao , Chunfang Xia
- 申请人： Hartmuth C. Kolb , Joseph C. Walsh , Dhanalakshmi Kasi , Vani P. Mocharla , Bing Wang , Umesh B. Gangadharmath , Brian A. Duclos , Kai Chen , Wei Zhang , Gang Chen , Henry Clifton Padgett , Farhad Karimi , Peter J. H. Scott , Zhiyong Gao , Qianwa Liang , Thomas Lee Collier , Tieming Zhao , Chunfang Xia
- 专利权人： SIEMENS MEDICAL SOLUTIONS USA, INC.
- 当前专利权人： SIEMENS MEDICAL SOLUTIONS USA, INC.
- 主分类号： C07D249/04
- IPC分类号： C07D249/04 ; C07D413/12 ; A61K49/04 ; A61K51/04
摘要：
The present application discloses methods for identifying inhibitors with high binding-affinity for the carbonic anhydrase-IX (CA-IX) enzyme using click chemistry and uses the candidates thereof as positron emission tomography (PET) imaging agents.