发明申请
US20090124820A1 C1-Symmetric Bisphospine Ligands and Their Use in the Asymmetric Synthesis of Pregabalin
审中-公开
C1对称双磷链配体及其在普拉巴林不对称合成中的应用
- 专利标题： C1-Symmetric Bisphospine Ligands and Their Use in the Asymmetric Synthesis of Pregabalin
- 专利标题（中）： C1对称双磷链配体及其在普拉巴林不对称合成中的应用
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申请号： US12353450申请日： 2009-01-14
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公开(公告)号： US20090124820A1公开(公告)日： 2009-05-14
- 发明人: Jian Bao , Vladimir G. Beylin , Derek Greene , Garrett S. Hoge , William Kissel , Mark Eugene Marlatt , Derek Andrew Pflum , He-Ping Wu
- 申请人： Jian Bao , Vladimir G. Beylin , Derek Greene , Garrett S. Hoge , William Kissel , Mark Eugene Marlatt , Derek Andrew Pflum , He-Ping Wu
- 专利权人： Pfizer Inc.
- 当前专利权人： Pfizer Inc.
- 主分类号： C07F15/00
- IPC分类号： C07F15/00 ; C07C229/02 ; C07F9/28
摘要：
Materials and Methods for preparing (S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid and structurally related compounds via enantioselective hydrogenation of prochiral olefins are disclosed. The methods employ novel chiral catalysts, which include C1-symmetric bisphosphine ligands bound to transition metals.
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