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发明申请
US20090131350A1 Hybrid Hepatocyte Growth Factor Gene Having High Expression Efficiency of Two Heterotypes of Hepatocyte Growth Factor 有权
具有两种肝细胞生长因子异型表达效率的混合型肝细胞生长因子基因

  • 专利标题： Hybrid Hepatocyte Growth Factor Gene Having High Expression Efficiency of Two Heterotypes of Hepatocyte Growth Factor
  • 专利标题（中）： 具有两种肝细胞生长因子异型表达效率的混合型肝细胞生长因子基因
  • 申请号： US11957170
    申请日： 2007-12-14
  • 公开(公告)号： US20090131350A1
    公开(公告)日： 2009-05-21
  • 发明人: Jong-Mook Kim , Woong Hahn
  • 申请人： Jong-Mook Kim , Woong Hahn
  • 专利权人： ViroMed, Co., Ltd.
  • 当前专利权人： ViroMed, Co., Ltd.
  • 优先权： KR10-2002-0015074 20020320
  • 主分类号： A61K31/7088
  • IPC分类号： A61K31/7088
Hybrid Hepatocyte Growth Factor Gene Having High Expression Efficiency of Two Heterotypes of Hepatocyte Growth Factor
摘要：
The present invention relates to a hybrid Hepatocyte Growth Factor (HGF) gene which is prepared by inserting an inherent or foreign intron between exons 4 and 5 in HGF cDNA, which has a base sequence of SEQ ID NO: 2. The gene has high expression efficiency and simultaneously expresses two heterotypes of HGF and dHGF (deleted variant HGF). Further the gene may be used for treating or preventing ischemic or liver diseases.
摘要（中）：

本发明涉及通过在具有SEQ ID NO：2的碱基序列的HGF cDNA中插入外显子4和5之间的固有或外来内含子而制备的混合肝细胞生长因子（HGF）基因。该基因具有高表达 并且同时表达HGF和dHGF（缺失变体HGF）的两种异型。 此外，该基因可用于治疗或预防缺血性或肝脏疾病。

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