公开(公告)号：US08389492B2

公开(公告)日：2013-03-05

申请号：US13045460

申请日：2011-03-10

申请人： Jong-Mook Kim ,  Sujeong Kim ,  Woong Hahn ,  WonSun Yoo

发明人： Jong-Mook Kim ,  Sujeong Kim ,  Woong Hahn ,  WonSun Yoo

IPC分类号： A61K31/7088

CPC分类号： C07K14/4753

摘要： The present invention provides for a method of treating or preventing ischemic or liver disease in a subject by administering a composition reconstituted from a lyophilized hepatocyte growth factor (HGF) DNA formulation, where the DNA formulation comprises an HGF plasmid DNA, salt and a carbohydrate. The invention further provides for a method of making such a lyophilized DNA formulation that preserves or enhances gene expression both in vitro and in vivo, thus maintaining or stimulating the biological activity of the expressed protein. The invention also provides for the DNA formulation, or the lyophilized DNA formulation according to the methods disclosed.

摘要翻译： 本发明提供了通过施用从冻干的肝细胞生长因子（HGF）DNA制剂重组的组合物来治疗或预防受试者的缺血性或肝脏疾病的方法，其中所述DNA制剂包含HGF质粒DNA，盐和碳水化合物。 本发明进一步提供了制备这样的冻干DNA制剂的方法，其在体外和体内保留或增强基因表达，从而维持或刺激所表达的蛋白质的生物学活性。 本发明还提供了根据所公开的方法的DNA制剂或冻干的DNA制剂。

公开(公告)号：US07838505B2

公开(公告)日：2010-11-23

申请号：US11957170

申请日：2007-12-14

申请人： Jong-Mook Kim ,  Woong Hahn

发明人： Jong-Mook Kim ,  Woong Hahn

IPC分类号： A01N43/04 ,  C12N15/63 ,  C12N15/85 ,  C12N15/86 ,  C12N1/20 ,  C12N1/19 ,  C12N15/00 ,  A61K48/00 ,  A61K31/70 ,  C12P21/00

CPC分类号： C07K14/4753

摘要： The present invention relates to a hybrid Hepatocyte Growth Factor (HGF) gene which is prepared by inserting an inherent or foreign intron between exons 4 and 5 in HGF cDNA, which has a base sequence of SEQ ID NO: 2. The gene has high expression efficiency and simultaneously expresses two heterotypes of HGF and dHGF (deleted variant HGF). Further the gene may be used for treating or preventing ischemic or liver diseases.

摘要翻译： 本发明涉及通过在具有SEQ ID NO：2的碱基序列的HGF cDNA中插入外显子4和5之间的固有或外来内含子而制备的混合肝细胞生长因子（HGF）基因。该基因具有高表达 并且同时表达HGF和dHGF（缺失变体HGF）的两种异型。 此外，该基因可用于治疗或预防缺血性或肝脏疾病。

公开(公告)号：US20060234516A1

公开(公告)日：2006-10-19

申请号：US11237100

申请日：2005-09-28

申请人： Eun Hong ,  Sang Ryu ,  Kang Shin ,  Kui Baek ,  Woong Hahn ,  Jung Lim ,  Sang Lee ,  Sung Kim ,  Hyun Kim

发明人： Eun Hong ,  Sang Ryu ,  Kang Shin ,  Kui Baek ,  Woong Hahn ,  Jung Lim ,  Sang Lee ,  Sung Kim ,  Hyun Kim

IPC分类号： H01L21/31

CPC分类号： H01L21/02071 ,  H01L21/02063

摘要： Provided are compositions for cleaning a semiconductor device that comprises (a) an inorganic acid in an amount ranging from 10 to 90 wt %, (b) a hydrofluoric acid compound in an amount ranging from 0.0001-1 wt %, (c) an additive in an amount ranging from 0-5 wt %, and (d) residual water to remove residuals of photoresist and metallic etching polymers which are generated in a dry etching process and an ashing process for manufacturing fine patterns of semiconductor device.

摘要翻译： 提供了一种用于清洁半导体器件的组合物，其包含（a）10至90重量％的无机酸，（b）0.0001-1重量％的氢氟酸化合物，（c）添加剂 以及（d）残留水以除去在干蚀刻工艺中产生的光致抗蚀剂和金属蚀刻聚合物的残留物以及用于制造半导体器件精细图案的灰化工艺。

公开(公告)号：US20100105878A1

公开(公告)日：2010-04-29

申请号：US12650860

申请日：2009-12-31

申请人： Jong-Mook Kim ,  Woong Hahn ,  Eun-Jin Park

发明人： Jong-Mook Kim ,  Woong Hahn ,  Eun-Jin Park

IPC分类号： C07K14/475 ,  C12N5/02 ,  C12N1/20 ,  C12N1/19

CPC分类号： C07K14/4753

摘要： The present invention relates to a hybrid Hepatocyte Growth Factor (HGF) gene which is prepared by inserting an inherent or foreign intron between exons 4 and 5 in HGF cDNA, which has a base sequence of SEQ ID NO: 2. The gene has high expression efficiency and simultaneously expresses two heterotypes of HGF and dHGF (deleted variant HGF). Further the gene may be used for treating or preventing ischemic or liver diseases.

摘要翻译： 本发明涉及通过在具有SEQ ID NO：2的碱基序列的HGF cDNA中插入外显子4和5之间的固有或外来内含子而制备的混合肝细胞生长因子（HGF）基因。该基因具有高表达 并且同时表达HGF和dHGF（缺失变体HGF）的两种异型。 此外，该基因可用于治疗或预防缺血性或肝脏疾病。

公开(公告)号：US20090312216A1

公开(公告)日：2009-12-17

申请号：US12063745

申请日：2006-08-05

申请人： Hyun Tak Kim ,  Seong Hwan Park ,  Jung Hun Lim ,  Sung Bae Kim ,  Chan Jin Jeong ,  Kui Jong Baek ,  Woong Hahn ,  Sang Won Lee ,  Gun-Woong Lee

发明人： Hyun Tak Kim ,  Seong Hwan Park ,  Jung Hun Lim ,  Sung Bae Kim ,  Chan Jin Jeong ,  Kui Jong Baek ,  Woong Hahn ,  Sang Won Lee ,  Gun-Woong Lee

IPC分类号： G03F7/42

CPC分类号： G03F7/425 ,  G03F7/426

摘要： The present invention relates to a photoresist stripper composition for removing the photoresist in the manufacturing process of the semiconductor device. More particularly, the photoresist stripper composition comprises 3-20 wt % of hydrazine hydrate or amine compound; 20˜40 wt % of polar solvent; 0.01-3 wt % of corrosion inhibitor selected from the group consisting of imidazoline derivative, sulfide derivative, sulfoxide derivative, aromatic compound or aromatic compound with hydroxyl group; 0.01-5 wt % of monoalcohol compound of C2-C10; and 40-70 wt % of deionized water. The photoresist stripper composition for manufacturing the semiconductor can remove the photoresist film thermoset by hard bake, dry etching, ashing or ion implantation and denatured by the metallic by-product etched from the bottom metallic film in said process at low temperature easily and quickly, and minimize the corrosion of the bottom metallic wiring in the removing process of the photoresist.

摘要翻译： 本发明涉及在半导体器件的制造过程中去除光致抗蚀剂的光致抗蚀剂剥离剂组合物。 更具体地，光刻胶剥离剂组合物包含3-20重量％的水合肼或胺化合物; 20〜40wt％极性溶剂; 0.01-3重量％的选自咪唑啉衍生物，硫化物衍生物，亚砜衍生物，芳族化合物或具有羟基的芳族化合物组成的组中的腐蚀抑制剂; 0.01-5重量％的C2-C10的一元醇化合物; 和40-70重量％的去离子水。 用于制造半导体的光致抗蚀剂剥离剂组合物可以通过硬烘烤，干蚀刻，灰化或离子注入去除光致抗蚀剂膜热固性，并且在低温下容易且快速地在所述工艺中从底部金属膜蚀刻的金属副产物变性， 在光致抗蚀剂的去除过程中最小化底部金属布线的腐蚀。

公开(公告)号：US20090202606A1

公开(公告)日：2009-08-13

申请号：US12359137

申请日：2009-01-23

申请人： Jong-Mook Kim ,  Sujeong Kim ,  Woong Hahn

发明人： Jong-Mook Kim ,  Sujeong Kim ,  Woong Hahn

IPC分类号： A61F2/00 ,  A61K38/16 ,  A61K31/7088

CPC分类号： A61K38/1833 ,  A61K31/70

摘要： The present invention relates to methods for treating or preventing cardiac conditions in a subject comprising administering to the subject two or more isoforms of hepatocyte growth factor (HGF). The present invention further relates to methods for promoting endothelial cell growth in a blood vessel comprising administering to the blood vessel two or more isoforms of hepatocyte growth factor (HGF). In one embodiment the two or more isoforms of HGF are administered as one or more polynucleotides encoding the isoforms.

摘要翻译： 本发明涉及用于治疗或预防受试者心脏病症的方法，其包括向受试者施用两种或更多种肝细胞生长因子（HGF）的同种型。 本发明还涉及促进血管内皮细胞生长的方法，包括向血管施用两种或多种肝细胞生长因子（HGF）的同种型。 在一个实施方案中，HGF的两种或更多种同种型作为编码同种型的一种或多种多核苷酸给药。

公开(公告)号：US20090131350A1

公开(公告)日：2009-05-21

申请号：US11957170

申请日：2007-12-14

申请人： Jong-Mook Kim ,  Woong Hahn

发明人： Jong-Mook Kim ,  Woong Hahn

IPC分类号： A61K31/7088

CPC分类号： C07K14/4753

摘要： The present invention relates to a hybrid Hepatocyte Growth Factor (HGF) gene which is prepared by inserting an inherent or foreign intron between exons 4 and 5 in HGF cDNA, which has a base sequence of SEQ ID NO: 2. The gene has high expression efficiency and simultaneously expresses two heterotypes of HGF and dHGF (deleted variant HGF). Further the gene may be used for treating or preventing ischemic or liver diseases.

摘要翻译： 本发明涉及通过在具有SEQ ID NO：2的碱基序列的HGF cDNA中插入外显子4和5之间的固有或外来内含子而制备的混合肝细胞生长因子（HGF）基因。该基因具有高表达 并且同时表达HGF和dHGF（缺失变体HGF）的两种异型。 此外，该基因可用于治疗或预防缺血性或肝脏疾病。

公开(公告)号：US08338385B2

公开(公告)日：2012-12-25

申请号：US12908765

申请日：2010-10-20

申请人： Jong-Mook Kim ,  Woong Hahn

发明人： Jong-Mook Kim ,  Woong Hahn

IPC分类号： A01N43/04 ,  C12N15/63 ,  C12N15/85 ,  C12N15/86 ,  C12N1/20 ,  C12N1/19 ,  C12N15/00 ,  A61K48/00 ,  A61K31/70 ,  C12P21/00

CPC分类号： C07K14/4753

摘要： The present invention relates to a hybrid Hepatocyte Growth Factor (HGF) gene which is prepared by inserting an inherent or foreign intron between exons 4 and 5 in HGF cDNA, which has a base sequence of SEQ ID NO: 2. The gene has high expression efficiency and simultaneously expresses two heterotypes of HGF and dHGF (deleted variant HGF). Further the gene may be used for treating or preventing ischemic or liver diseases.

摘要翻译： 本发明涉及通过在具有SEQ ID NO：2的碱基序列的HGF cDNA中插入外显子4和5之间的固有或外来内含子而制备的混合肝细胞生长因子（HGF）基因。该基因具有高表达 并且同时表达HGF和dHGF（缺失变体HGF）的两种异型。 此外，该基因可用于治疗或预防缺血性或肝脏疾病。

公开(公告)号：US07851372B2

公开(公告)日：2010-12-14

申请号：US11540604

申请日：2006-10-02

申请人： Dong-Min Kang ,  Kui-Jong Baek ,  Woong Hahn ,  Chun-Deuk Lee ,  Jung-Hun Lim ,  Young-Nam Kim ,  Hyun-Joon Kim

发明人： Dong-Min Kang ,  Kui-Jong Baek ,  Woong Hahn ,  Chun-Deuk Lee ,  Jung-Hun Lim ,  Young-Nam Kim ,  Hyun-Joon Kim

IPC分类号： H01L21/461

CPC分类号： H01L21/31111 ,  H01L21/02079

摘要： In one aspect, a composition is provided which is capable of removing an insulation material which includes at least one of a low-k material and a passivation material. The composition of this aspect includes about 5 to about 40 percent by weight of a fluorine compound, about 0.01 to about 20 percent by weight of a first oxidizing agent, about 10 to about 50 percent by weight of a second oxidizing agent, and a remaining water.

摘要翻译： 在一个方面，提供了能够去除包括低k材料和钝化材料中的至少一种的绝缘材料的组合物。 该方面的组成包括约5至约40重量％的氟化合物，约0.01至约20重量％的第一氧化剂，约10至约50重量％的第二氧化剂，以及剩余的 水。

公开(公告)号：US07812146B2

公开(公告)日：2010-10-12

申请号：US10944277

申请日：2004-09-20

申请人： Jong-Mook Kim ,  Woong Hahn ,  Eun-Jin Park

发明人： Jong-Mook Kim ,  Woong Hahn ,  Eun-Jin Park

IPC分类号： C07H21/04 ,  C12N15/63 ,  C12N15/85 ,  C12N15/86 ,  C12N1/20 ,  C12N1/19 ,  C12N15/00 ,  A61K48/00 ,  C12P21/00

CPC分类号： C07K14/4753

摘要： The present invention relates to a hybrid Hepatocyte Growth Factor (HGF) gene which is prepared by inserting an inherent or foreign intron between exons 4 and 5 in HGF cDNA, which has a base sequence of SEQ ID NO: 2. The gene has high expression efficiency and simultaneously expresses two heterotypes of HGF and dHGF (deleted variant HGF). Further the gene may be used for treating or preventing ischemic or liver diseases.