发明申请
US20090131483A1 2-PYRIDINE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE
审中-公开
作为中性弹性蛋白酶抑制剂的2-吡啶衍生物
- 专利标题： 2-PYRIDINE DERIVATIVES AS INHIBITORS OF NEUTROPHILE ELASTASE
- 专利标题（中）： 作为中性弹性蛋白酶抑制剂的2-吡啶衍生物
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申请号： US11908746申请日： 2006-03-14
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公开(公告)号： US20090131483A1公开(公告)日： 2009-05-21
- 发明人: Peter Hansen , Karolina Lawitz , Hans Lonn , Antonios Nikitidis
- 申请人： Peter Hansen , Karolina Lawitz , Hans Lonn , Antonios Nikitidis
- 优先权： SE0500604-4 20050316
- 国际申请： PCT/SE2006/000327 WO 20060314
- 主分类号： A61K31/4439
- IPC分类号： A61K31/4439 ; C07D413/14 ; C07D413/02 ; A61P29/00 ; A61P11/00 ; A61K31/44 ; C07D213/81
摘要：
The invention provides compounds of formula (I) wherein R1, R2, R3, R4, R5 and X are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.