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公开(公告)号：US20090131483A1
公开(公告)日：2009-05-21
申请号：US11908746
申请日：2006-03-14
申请人： Peter Hansen , Karolina Lawitz , Hans Lonn , Antonios Nikitidis
发明人： Peter Hansen , Karolina Lawitz , Hans Lonn , Antonios Nikitidis
IPC分类号： A61K31/4439 , C07D413/14 , C07D413/02 , A61P29/00 , A61P11/00 , A61K31/44 , C07D213/81
CPC分类号： C07D213/82 , C07D413/12 , C07D413/14
摘要： The invention provides compounds of formula (I) wherein R1, R2, R3, R4, R5 and X are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.
摘要翻译： 本发明提供式（I）化合物，其中R 1，R 2，R 3，R 4，R 5和X如说明书中所定义，并且其旋光异构体，外消旋体和互变异构体及其药学上可接受的盐; 以及其制备方法，含有它们的药物组合物及其在治疗中的用途。 这些化合物是人嗜中性粒细胞弹性蛋白酶的抑制剂。
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2.发明授权2-pyrazinone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial 失效2-吡嗪酮衍生物用于治疗嗜中性粒细胞弹性蛋白酶活性抑制有益的疾病或病症公开(公告)号：US08410114B2
公开(公告)日：2013-04-02
申请号：US13344658
申请日：2012-01-06
申请人： Peter Hansen , Marianne Ivarsson , Karolina Lawitz , Hans Lonn , Antonios Nikitidis , Asim Ray
发明人： Peter Hansen , Marianne Ivarsson , Karolina Lawitz , Hans Lonn , Antonios Nikitidis , Asim Ray
IPC分类号： A61K31/4965
CPC分类号： C07D401/14 , C07D401/12 , C07D403/04 , C07D403/14
摘要： The invention provides compounds of formula wherein R1, R3, R4, R5, R14, X and W are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.
摘要翻译： 本发明提供下列结构的化合物，其中R 1，R 3，R 4，R 5，R 14，X和W如说明书中所定义，并且其旋光异构体，外消旋体和互变异构体及其药学上可接受的盐; 以及其制备方法，含有它们的药物组合物及其在治疗中的用途。 这些化合物是人嗜中性粒细胞弹性蛋白酶的抑制剂。
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3.发明申请2-PYRAZINONE DERIVATIVES FOR THE TREATMENT OF DISEASE OR CONDITION IN WHICH INHIBITION OF NEUTROPHIL ELASTASE ACTIVITY IS BENEFICIAL 失效用于治疗抑制中性粒细胞活化的疾病或病症的2-吡嗪酮衍生物是有益的公开(公告)号：US20120108610A1
公开(公告)日：2012-05-03
申请号：US13344658
申请日：2012-01-06
申请人： Peter Hansen , Marianne Ivarsson , Karolina Lawitz , Hans Lonn , Antonios Nikitidis , Asim Ray
发明人： Peter Hansen , Marianne Ivarsson , Karolina Lawitz , Hans Lonn , Antonios Nikitidis , Asim Ray
IPC分类号： A61K31/497 , C07D401/14 , C07D401/04 , A61P29/00 , A61P11/00 , A61P1/00 , A61P17/06 , A61P19/02 , A61P9/10 , A61P17/02 , A61P1/04 , C07D403/04 , A61P11/06
CPC分类号： C07D401/14 , C07D401/12 , C07D403/04 , C07D403/14
摘要： The invention provides compounds of formula wherein R1, R3, R4, R5, R14, X and W are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.
摘要翻译： 本发明提供下列结构的化合物，其中R 1，R 3，R 4，R 5，R 14，X和W如说明书中所定义，并且其旋光异构体，外消旋物和互变异构体及其药学上可接受的盐; 以及其制备方法，含有它们的药物组合物及其在治疗中的用途。 这些化合物是人嗜中性粒细胞弹性蛋白酶的抑制剂。
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4.发明申请2-Pyridone derivatives as neutrophil elastase inhibitors and their use 审中-公开2-吡啶酮衍生物作为嗜中性粒细胞弹性蛋白酶抑制剂及其应用公开(公告)号：US20070043036A1
公开(公告)日：2007-02-22
申请号：US10572640
申请日：2004-09-15
申请人： Peter Hansen , Karolina Lawitz , Hans Lonn , Antonios Nikitidis
发明人： Peter Hansen , Karolina Lawitz , Hans Lonn , Antonios Nikitidis
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/497 , A61K31/496 , A61K31/4965 , A61K31/4439 , A61K31/4415 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D213/82 , C07D213/85 , C07D401/04
摘要： There are provided novel compounds of formula (I), wherein R1, R2, R4, R5, G1, G2, L, Y and n are as defined in the Specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of neutrophil elastase.
摘要翻译： 提供了新的式（I）化合物，其中R 1，R 2，R 4，R 5， G 1，G 2，L 2，Y 2和n如本说明书和光学异构体，外消旋体和互变异构体及其药学上可接受的盐所定义; 以及其制备方法，含有它们的组合物及其在治疗中的用途。 这些化合物是嗜中性粒细胞弹性蛋白酶抑制剂。
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公开(公告)号：US20090105239A1
公开(公告)日：2009-04-23
申请号：US11908748
申请日：2006-03-14
申请人： Thomas Brimert , Karolina Lawitz , Hans Lonn , Antonios Nikitidis , Asim Kumar Ray , Jenny Sandmark
发明人： Thomas Brimert , Karolina Lawitz , Hans Lonn , Antonios Nikitidis , Asim Kumar Ray , Jenny Sandmark
IPC分类号： A61K31/5377 , C07D213/63 , A61K31/44 , A61K31/4439 , C07D413/02 , C07D401/02 , A61K31/444
CPC分类号： C07D213/82 , C07D413/12 , C07D413/14
摘要： The invention provides compounds of formula wherein R1, R3, R4, R5, R6, R14, X, W and Z are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.
摘要翻译： 本发明提供了下列结构的化合物，其中R 1，R 3，R 4，R 5，R 6，R 14，X，W和Z如本说明书和光学异构体，外消旋体和互变异构体及其药学上可接受的盐所定义; 以及其制备方法，含有它们的药物组合物及其在治疗中的用途。 这些化合物是人嗜中性粒细胞弹性蛋白酶的抑制剂。
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6.发明申请2-PYRAZINONE DERIVATIVES FOR THE TREATMENT OF DISEASE OR CONDITION IN WHICH INHIBITION OF NEUTROPHIL ELASTASE ACTIVITY IS BENEFICIAL 失效用于治疗抑制中性粒细胞活化的疾病或病症的2-吡嗪酮衍生物是有益的公开(公告)号：US20090209555A1
公开(公告)日：2009-08-20
申请号：US12299878
申请日：2007-05-07
申请人： Peter Hansen , Marianne Ivarsson , Karolina Lawitz , Hans Lönn , Antonios Nikitidis , Asim Ray
发明人： Peter Hansen , Marianne Ivarsson , Karolina Lawitz , Hans Lönn , Antonios Nikitidis , Asim Ray
IPC分类号： A61K31/497 , C07D403/02 , C07D403/14 , A61P11/00 , A61P35/00 , A61P1/00 , A61P29/00
CPC分类号： C07D401/14 , C07D401/12 , C07D403/04 , C07D403/14
摘要： The invention provides compounds of formula wherein R1, R3, R4, R5, R14, X and W are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.
摘要翻译： 本发明提供下列结构的化合物，其中R 1，R 3，R 4，R 5，R 14，X和W如说明书中所定义，并且其旋光异构体，外消旋体和互变异构体及其药学上可接受的盐; 以及其制备方法，含有它们的药物组合物及其在治疗中的用途。 这些化合物是人嗜中性粒细胞弹性蛋白酶的抑制剂。
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7.发明授权2-pyrazinone derivatives for the treatment of disease or condition in which inhibition of neutrophil elastase activity is beneficial 失效2-吡嗪酮衍生物用于治疗嗜中性粒细胞弹性蛋白酶活性抑制有益的疾病或病症公开(公告)号：US08114881B2
公开(公告)日：2012-02-14
申请号：US12299878
申请日：2007-05-07
申请人： Peter Hansen , Marianne Ivarsson , Karolina Lawitz , Hans Lönn , Antonios Nikitidis , Asim Ray
发明人： Peter Hansen , Marianne Ivarsson , Karolina Lawitz , Hans Lönn , Antonios Nikitidis , Asim Ray
IPC分类号： A61K31/4965
CPC分类号： C07D401/14 , C07D401/12 , C07D403/04 , C07D403/14
摘要： The invention provides compounds of formula wherein R1, R3, R4, R5, R14, X and W are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.
摘要翻译： 本发明提供下列结构的化合物，其中R 1，R 3，R 4，R 5，R 14，X和W如说明书中所定义，并且其旋光异构体，外消旋体和互变异构体及其药学上可接受的盐; 以及其制备方法，含有它们的药物组合物及其在治疗中的用途。 这些化合物是人嗜中性粒细胞弹性蛋白酶的抑制剂。
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8.发明授权2-pyridone derivatives as neutrophil elastase inhibitors and their use 有权2-吡啶酮衍生物作为嗜中性粒细胞弹性蛋白酶抑制剂及其应用公开(公告)号：US08501784B2
公开(公告)日：2013-08-06
申请号：US13273860
申请日：2011-10-14
IPC分类号： A61K31/44 , C07D401/02
CPC分类号： C07D213/82 , C04B35/632 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04
摘要： There are provided novel compounds of formula (I), wherein R1, R2, R4, G1, G2, L, Y and n are as defined in the Specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of neutrophil elastase.
摘要翻译： 提供新的式（I）化合物，其中R1，R2，R4，G1，G2，L，Y和n如本说明书和光学异构体，外消旋体和互变异构体及其药学上可接受的盐所定义; 以及其制备方法，含有它们的组合物及其在治疗中的用途。 这些化合物是嗜中性粒细胞弹性蛋白酶抑制剂。
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9.发明申请2-Pyridone Derivatives As Neutrophil Elastase Inhibitors And Their Use 有权2-吡啶酮衍生物作为中性粒细胞弹性蛋白酶抑制剂及其用途公开(公告)号：US20070203129A1
公开(公告)日：2007-08-30
申请号：US10572706
申请日：2004-09-15
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/4965 , A61K31/497 , A61K31/496 , A61K31/4439 , C07D403/02 , C07D413/02 , C07D417/02
CPC分类号： C07D213/82 , C04B35/632 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04
摘要： There are provided novel compounds of formula (I), wherein R1, R2, R4, R5, G1, G2, L, Y and n are as defined in the Specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of neutrophil elastase.
摘要翻译： 提供了新的式（I）化合物，其中R 1，R 2，R 4，R 5， G 1，G 2，L 2，Y 2和n如本说明书和光学异构体，外消旋体和互变异构体及其药学上可接受的盐所定义; 以及其制备方法，含有它们的组合物及其在治疗中的用途。 这些化合物是嗜中性粒细胞弹性蛋白酶抑制剂。
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公开(公告)号：US20080153799A1
公开(公告)日：2008-06-26
申请号：US10597896
申请日：2005-02-07
IPC分类号： A61K31/397 , C07D215/00 , A61K31/47 , C07D295/00 , C07D217/00 , A61P37/00 , A61K31/5377 , A61K31/541 , A61K31/496
CPC分类号： C07D409/12 , C07D215/54 , C07D401/12 , C07D405/12 , C07D417/12
摘要： The present invention relates to novel compounds which are JAK3 Kinase inhibitors, methods for their preparation and pharmaceutical compositions comprising them. A compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, wherein X is —CHOH or —C═O;
摘要翻译： 本发明涉及作为JAK3激酶抑制剂的新化合物，其制备方法和包含它们的药物组合物。 式（I）化合物或其药学上可接受的盐或溶剂合物，其中X为-CHOH或-C-O;
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