发明申请
US20090131491A1 ISOXAZOLE DERIVATIVE AND ISOTHIAZOLE DERIVATIVE HAVING INHIBITORY ACTIVITY ON 11(beta)-HYDROXYSTEROID DEHYDROGENASE TYPE I
有权
含有11（β） - 羟基脱氢酶脱氢酶I型的异噻唑衍生物和异噻唑衍生物具有抑制活性
- 专利标题： ISOXAZOLE DERIVATIVE AND ISOTHIAZOLE DERIVATIVE HAVING INHIBITORY ACTIVITY ON 11(beta)-HYDROXYSTEROID DEHYDROGENASE TYPE I
- 专利标题（中）： 含有11（β） - 羟基脱氢酶脱氢酶I型的异噻唑衍生物和异噻唑衍生物具有抑制活性
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申请号： US12293246申请日： 2007-03-28
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公开(公告)号： US20090131491A1公开(公告)日： 2009-05-21
- 发明人: Tomoyuki Ogawa , Nobuo Chomei , Koji Masuda , Satoru Tanaka
- 申请人： Tomoyuki Ogawa , Nobuo Chomei , Koji Masuda , Satoru Tanaka
- 申请人地址： JP Osaka-shi, Osaka
- 专利权人： SHIONOGI & CO., LTD.
- 当前专利权人： SHIONOGI & CO., LTD.
- 当前专利权人地址： JP Osaka-shi, Osaka
- 优先权： JP2006-094057 20060330; JP2006-280893 20061016
- 国际申请： PCT/JP2007/056538 WO 20070328
- 主分类号： A61K31/42
- IPC分类号： A61K31/42 ; C07D261/02 ; A61P3/10
摘要：
Disclosed is a compound useful as an inhibitor of 11β-hydroxysteroid dehydrogenase type 1.A compound represented by the formula: a pharmaceutically acceptable salt or solvate thereof, wherein R1 is a group of the formula: —C(═O)NR4R5, (wherein R4 and R5 are each independently, hydrogen, optionally substituted alkyl or the like) or a group of the formula: —NR6C(═O)R7, (wherein R6 and R7 are each independently, hydrogen, optionally substituted alkyl or the like), X and Y are each independently —O— or the like, Z is a bond or the like, R2 is optionally substituted alkyl, optionally substituted alkenyl or the like, R3 is optionally substituted alkyl, optionally substituted alkenyl or the like.
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