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    Isoxazole derivative and isothiazole derivative having inhibitory activity on 11β-hydroxysteroid dehydrogenase type 1
    1.
    发明授权
    Isoxazole derivative and isothiazole derivative having inhibitory activity on 11β-hydroxysteroid dehydrogenase type 1 有权
    具有抑制活性的异恶唑衍生物和异噻唑衍生物

    公开(公告)号：US08017638B2

    公开(公告)日：2011-09-13

    申请号：US12293246

    申请日：2007-03-28

    申请人： Tomoyuki Ogawa ,  Nobuo Chomei ,  Koji Masuda ,  Satoru Tanaka

    发明人： Tomoyuki Ogawa ,  Nobuo Chomei ,  Koji Masuda ,  Satoru Tanaka

    IPC分类号： A61K31/42 ,  C07D261/06

    CPC分类号： C07D261/18 ,  C07D275/02 ,  C07D413/12 ,  C07D417/12 ,  C07D471/10

    摘要： Disclosed is a compound useful as an inhibitor of 11β-hydroxysteroid dehydrogenase type 1.A compound represented by the formula: a pharmaceutically acceptable salt or solvate thereof, wherein R1 is a group of the formula: —C(═O)NR4R5, (wherein R4 and R5 are each independently, hydrogen, optionally substituted alkyl or the like) or a group of the formula: —NR6C(═O)R7, (wherein R6 and R7 are each independently, hydrogen, optionally substituted alkyl or the like), X and Y are each independently —O— or the like, Z is a bond or the like, R2 is optionally substituted alkyl, optionally substituted alkenyl or the like, R3 is optionally substituted alkyl, optionally substituted alkenyl or the like.

    摘要翻译： 公开了一种可用作11型β-羟基类固醇脱氢酶抑制剂的化合物。下式表示的化合物：其药学上可接受的盐或溶剂合物，其中R 1是下式的基团：-C（= O）NR 4 R 5，（ 其中R 4和R 5各自独立地为氢，任选取代的烷基等）或下式的基团：-NR 6 C（= O）R 7，（其中R 6和R 7各自独立地为氢，任选取代的烷基等） X和Y各自独立地为-O-等，Z为键或类似物，R 2为任选取代的烷基，任选取代的烯基等，R 3为任选取代的烷基，任选取代的烯基等。

    ISOXAZOLE DERIVATIVE AND ISOTHIAZOLE DERIVATIVE HAVING INHIBITORY ACTIVITY ON 11(beta)-HYDROXYSTEROID DEHYDROGENASE TYPE I
    2.
    发明申请
    ISOXAZOLE DERIVATIVE AND ISOTHIAZOLE DERIVATIVE HAVING INHIBITORY ACTIVITY ON 11(beta)-HYDROXYSTEROID DEHYDROGENASE TYPE I 有权
    含有11（β） - 羟基脱氢酶脱氢酶I型的异噻唑衍生物和异噻唑衍生物具有抑制活性

    公开(公告)号：US20090131491A1

    公开(公告)日：2009-05-21

    申请号：US12293246

    申请日：2007-03-28

    申请人： Tomoyuki Ogawa ,  Nobuo Chomei ,  Koji Masuda ,  Satoru Tanaka

    发明人： Tomoyuki Ogawa ,  Nobuo Chomei ,  Koji Masuda ,  Satoru Tanaka

    IPC分类号： A61K31/42 ,  C07D261/02 ,  A61P3/10

    CPC分类号： C07D261/18 ,  C07D275/02 ,  C07D413/12 ,  C07D417/12 ,  C07D471/10

    摘要： Disclosed is a compound useful as an inhibitor of 11β-hydroxysteroid dehydrogenase type 1.A compound represented by the formula: a pharmaceutically acceptable salt or solvate thereof, wherein R1 is a group of the formula: —C(═O)NR4R5, (wherein R4 and R5 are each independently, hydrogen, optionally substituted alkyl or the like) or a group of the formula: —NR6C(═O)R7, (wherein R6 and R7 are each independently, hydrogen, optionally substituted alkyl or the like), X and Y are each independently —O— or the like, Z is a bond or the like, R2 is optionally substituted alkyl, optionally substituted alkenyl or the like, R3 is optionally substituted alkyl, optionally substituted alkenyl or the like.

    摘要翻译： 公开了用作11β-羟类固醇脱氢酶1型抑制剂的化合物。下式表示的化合物：其药学上可接受的盐或溶剂合物，其中R 1是下式的基团：-C（-O）NR 4 R 5，（其中 R 4和R 5各自独立地为氢，任选取代的烷基等）或下式-NR 6 C（-O）R 7的基团（其中R 6和R 7各自独立地为氢，任选取代的烷基等）， X和Y各自独立地为-O-等，Z为键或类似物，R 2为任选取代的烷基，任选取代的烯基等，R 3为任选取代的烷基，任选取代的烯基等。

    NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE HAVING 11SS-HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORY ACTIVITY
    4.
    发明申请
    NITROGEN-CONTAINING HETEROCYCLIC DERIVATIVE HAVING 11SS-HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORY ACTIVITY 有权
    含有11SS-羟基脱氢酶脱氢酶I型抑制活性的含氮杂环衍生物

    公开(公告)号：US20100240659A1

    公开(公告)日：2010-09-23

    申请号：US12599133

    申请日：2008-05-07

    申请人： Koji Masuda ,  Tomoyuki Ogawa ,  Takuji Nakatani

    发明人： Koji Masuda ,  Tomoyuki Ogawa ,  Takuji Nakatani

    IPC分类号： A61K31/5377 ,  C07D231/10 ,  A61K31/415 ,  C07D271/10 ,  A61K31/4245 ,  C07D263/04 ,  A61K31/421 ,  C07D413/12 ,  A61P3/10

    CPC分类号： C07D231/14 ,  C07D231/16 ,  C07D231/18 ,  C07D231/20 ,  C07D231/38 ,  C07D405/12 ,  C07D413/06

    摘要： Disclosed is a compound which is useful as an 11β-hydroxysteroid dehydrogenase type 1 inhibitor.A compound represented by the formula: , its pharmaceutically acceptable salt, or a solvate thereof, wherein Ring A is a group represented by the formula: Ring B is optionally substituted heteroaryl, provided that optionally substituted isoxazole is excluded, or optionally substituted heterocycle, R1 is hydrogen or optionally substituted alkyl, R2 is —OR5, —SR5, halogen, halogenated alkyl or the like, R3 is optionally substituted alkyl or the like, R4 is optionally substituted alkyl or the like, R5 is optionally substituted alkyl or the like, R6 is hydrogen or the like, R7 and R8 are each independently hydrogen or the like, R10 and R11 are each independently hydrogen or the like, R12 is optionally substituted alkyl or the like, m and p are each independently integer of 1 to 3.

    摘要翻译： 公开了可用作11-羟基类固醇脱氢酶1型抑制剂的化合物。 由下式表示的化合物，其药学上可接受的盐或其溶剂合物，其中环A是下式表示的基团：环B是任选取代的杂芳基，条件是排除任选取代的异唑或任选取代的杂环，R 1 R 3为任选取代的烷基等，R 4为任选取代的烷基等，R 5为任选取代的烷基等，R 5为任选取代的烷基， R 6是氢等，R 7和R 8各自独立地为氢等，R 10和R 11各自独立地为氢等，R 12为任选取代的烷基等，m和p各自为1〜3的整数。

    Nitrogen-containing heterocyclic derivative having 11β-hydroxysteroid dehydrogenase type I inhibitory activity
    6.
    发明授权
    Nitrogen-containing heterocyclic derivative having 11β-hydroxysteroid dehydrogenase type I inhibitory activity 有权
    具有11β-羟基类固醇脱氢酶I型抑制活性的含氮杂环衍生物

    公开(公告)号：US08383622B2

    公开(公告)日：2013-02-26

    申请号：US12599133

    申请日：2008-05-07

    申请人： Koji Masuda ,  Tomoyuki Ogawa ,  Takuji Nakatani

    发明人： Koji Masuda ,  Tomoyuki Ogawa ,  Takuji Nakatani

    IPC分类号： A61K31/5377 ,  A61K31/415 ,  A61K31/4245 ,  A61K31/421 ,  C07D231/10 ,  C07D271/10 ,  C07D263/04 ,  C07D413/12 ,  A61P3/10

    CPC分类号： C07D231/14 ,  C07D231/16 ,  C07D231/18 ,  C07D231/20 ,  C07D231/38 ,  C07D405/12 ,  C07D413/06

    摘要： Disclosed is a compound which is useful as an 11β-hydroxysteroid dehydrogenase type 1 inhibitor.A compound represented by the formula: its pharmaceutically acceptable salt, or a solvate thereof, wherein Ring A is a group represented by the formula: Ring B is optionally substituted heteroaryl, provided that optionally substituted isoxazole is excluded, or optionally substituted heterocycle, R1 is hydrogen or optionally substituted alkyl, R2 is —OR5, —SR5, halogen, halogenated alkyl or the like, R3 is optionally substituted alkyl or the like, R4 is optionally substituted alkyl or the like, R5 is optionally substituted alkyl or the like, R6 is hydrogen or the like, R7 and R8 are each independently hydrogen or the like, R10 and R11 are each independently hydrogen or the like, R12 is optionally substituted alkyl or the like, m and p are each independently integer of 1 to 3.

    摘要翻译： 公开了可用作11-羟基类固醇脱氢酶1型抑制剂的化合物。 由下式表示的化合物：其药学上可接受的盐或其溶剂合物，其中环A是由下式表示的基团：环B是任选取代的杂芳基，条件是排除任选取代的异唑或任选取代的杂环，R 1是 氢或任选取代的烷基，R 2是-OR 5，-SR 5，卤素，卤代烷基等，R 3是任选取代的烷基等，R 4是任选取代的烷基等，R 5是任选取代的烷基等，R 6 是氢等，R 7和R 8各自独立地为氢等，R 10和R 11各自独立地为氢等，R 12为任选取代的烷基等，m和p各自独立地为1〜3的整数。

    Image forming apparatus and image forming method
    9.
    发明授权
    Image forming apparatus and image forming method 有权

    公开(公告)号：US09442438B2

    公开(公告)日：2016-09-13

    申请号：US14812625

    申请日：2015-07-29

    申请人： Koji Masuda ,  Hidemasa Suzuki ,  Susumu Momma

    发明人： Koji Masuda ,  Hidemasa Suzuki ,  Susumu Momma

    IPC分类号： G03G15/20 ,  G03G15/00

    CPC分类号： G03G15/2039 ,  G03G15/2053 ,  G03G15/55

    摘要： An image forming apparatus includes a charging device configured to uniformly charge a surface of a photoconductive element; an image writing device configured to write an image in the charged photoconductive element by light to form an electrostatic latent image; a developing device configured to visualize the formed electrostatic latent image as a toner image; a transfer device configured to transfer the toner image to a sheet recording medium; a fixing device configured to fix the transferred toner image onto the medium; and a surface information detecting device configured to detect surface information of a fixing member of the fixing device. The surface information detecting device radiates optical spots on a surface of the fixing member in a direction crossing a conveying direction, receives reflected light of each optical spot, and detects the surface information of the fixing device based on the detection results of the reflective lights.

    Reflective optical sensor, image forming apparatus, and surface information detecting method
    10.
    发明授权
    Reflective optical sensor, image forming apparatus, and surface information detecting method 有权
    反射光学传感器，图像形成装置和表面信息检测方法

    公开(公告)号：US09431445B2

    公开(公告)日：2016-08-30

    申请号：US14815028

    申请日：2015-07-31

    申请人： Susumu Momma ,  Kazuya Miyagaki ,  Koji Masuda ,  Hidemasa Suzuki

    发明人： Susumu Momma ,  Kazuya Miyagaki ,  Koji Masuda ,  Hidemasa Suzuki

    IPC分类号： G03G15/20 ,  H01L27/146 ,  G03G15/00

    CPC分类号： H01L27/14625 ,  G03G15/2039 ,  G03G15/2053 ,  G03G15/553 ,  H01L27/14618

    摘要： A reflective optical sensor for detecting surface information on a moving element moving in a certain direction includes at least one light emitter, a light emitting lens provided between the light emitter and a surface of the moving element and formed to become conjugated with the light emitter in the moving direction of the moving element in a longer distance from the light emitter than in a vertical direction relative to the moving direction, at least one light receiver, and a light receiving lens provided between the light receiver and the surface of the moving element.

    摘要翻译： 用于检测在一定方向上移动的移动元件上的表面信息的反射光学传感器包括至少一个光发射器，设置在光发射器和移动元件的表面之间并形成为与光发射器共轭的发光透镜 移动元件相对于移动方向距离发光体的距离比垂直方向更长的移动方向，至少一个光接收器和设置在光接收器和移动元件的表面之间的光接收透镜。