发明申请
US20090136473A1 BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS
审中-公开
用于治疗肺动脉和心脏病的BIARYL PDE4抑制剂
- 专利标题： BIARYL PDE4 INHIBITORS FOR TREATING PULMONARY AND CARDIOVASCULAR DISORDERS
- 专利标题（中）： 用于治疗肺动脉和心脏病的BIARYL PDE4抑制剂
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申请号： US12275152申请日： 2008-11-20
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公开(公告)号： US20090136473A1公开(公告)日： 2009-05-28
- 发明人: Jasbir Singh , Mark E. Gurney , Alex Burgin , Alexander Kiselyov , Munagala Rao , Timothy Hagen
- 申请人： Jasbir Singh , Mark E. Gurney , Alex Burgin , Alexander Kiselyov , Munagala Rao , Timothy Hagen
- 申请人地址： IS Reykjavik
- 专利权人： DECODE GENETICS EHF
- 当前专利权人： DECODE GENETICS EHF
- 当前专利权人地址： IS Reykjavik
- 主分类号： A61K31/44
- IPC分类号： A61K31/44 ; C07D231/12 ; C07D213/64 ; C07D239/42 ; C07D213/79 ; C07C275/28 ; C07D285/135 ; A61K31/433 ; A61K31/4439 ; A61P1/00 ; A61P11/00 ; A61P35/00 ; A61P9/00 ; A61K31/122 ; A61K31/4353 ; A61K31/435 ; A61K31/4427 ; A61K31/437 ; A61K31/4545 ; C07D401/06 ; C07D471/04 ; C07D213/72 ; A61K31/415 ; A61K31/4412 ; A61K31/495
摘要：
The present invention relates to a genus of biaryl compounds containing at least one further ring. The compounds are PDE4 inhibitors useful for the treatment and prevention of stroke, myocardial infarct and cardiovascular inflammatory diseases and disorders. The compounds have general formula Ia, Ib, Ic or Id: A particular embodiment is
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