发明申请
- 专利标题： CD10-activated prodrug compounds
- 专利标题（中）： CD10活化前药化合物
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申请号： US11986096申请日： 2007-11-20
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公开(公告)号： US20090136980A1公开(公告)日： 2009-05-28
- 发明人: Christopher R. Bebbington , Matthew H. Nieder , Pina M. Cardarelli , Sanjeev Gangwar , Lesley B. Pickford , Chin Pan
- 申请人： Christopher R. Bebbington , Matthew H. Nieder , Pina M. Cardarelli , Sanjeev Gangwar , Lesley B. Pickford , Chin Pan
- 申请人地址： US NJ Princeton
- 专利权人： MEDAREX, INC.
- 当前专利权人： MEDAREX, INC.
- 当前专利权人地址： US NJ Princeton
- 主分类号： C12Q1/37
- IPC分类号： C12Q1/37
摘要：
The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the CD10 enzyme. Methods of treatment using the prodrug and methods of designing the prodrug are also disclosed.
公开/授权文献
- US07771962B2 CD10-activated prodrug compounds 公开/授权日：2010-08-10
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