发明申请
US20090137420A1 METHODS, COMPOUNDS AND COMPOSITIONS WITH GENOTYPE SELECTIVE ANTICANCER ACTIVITY
有权
方法，化合物和组合物与基因选择性反应活性
- 专利标题： METHODS, COMPOUNDS AND COMPOSITIONS WITH GENOTYPE SELECTIVE ANTICANCER ACTIVITY
- 专利标题（中）： 方法，化合物和组合物与基因选择性反应活性
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申请号： US11910591申请日： 2006-04-14
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公开(公告)号： US20090137420A1公开(公告)日： 2009-05-28
- 发明人: Daniel D. Von Hoff , Haiyong Han , Hong Wang , Gary A. Flynn
- 申请人： Daniel D. Von Hoff , Haiyong Han , Hong Wang , Gary A. Flynn
- 专利权人： TRANSLATIONAL GENOMLES, RESEARCH INSTITUTE
- 当前专利权人： TRANSLATIONAL GENOMLES, RESEARCH INSTITUTE
- 国际申请： PCT/US2006/013900 WO 20060414
- 主分类号： C40B30/06
- IPC分类号： C40B30/06 ; C07C233/77 ; C07D263/32 ; C07D231/54 ; C07D277/46
摘要：
This invention is directed to methods for screening and identification of compounds capable of selectively eliminating cancer cells with specific loss-of-function alterations, including but not limited to mutations, deletions, hypermethylations, and other types of gene silencing. This invention is also directed to novel compounds that selectively eliminate cancer cells with specific loss-of-function alterations. Furthermore, this invention is directed to methods for production and therapeutic use of compounds that selectively eliminate cancer cells with specific loss-of-function alterations.
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