发明申请
- 专利标题： NGF VARIANTS
- 专利标题（中）： NGF变种
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申请号： US12254458申请日： 2008-10-20
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公开(公告)号： US20090137471A1公开(公告)日： 2009-05-28
- 发明人: Leonard G. Presta , Roman Urfer , John W. Winslow
- 申请人： Leonard G. Presta , Roman Urfer , John W. Winslow
- 主分类号： A61K38/18
- IPC分类号： A61K38/18 ; C07K14/48 ; C12N15/12 ; A61P25/00 ; C12N1/15 ; C12N5/10 ; C12N1/19 ; C12N1/21 ; C12N15/63 ; C12P21/00
摘要：
NGF variants which have trkC-binding activity and trkC-signal inducing activity are provided. The variants optionally have trkA or trkB binding and signal induction activity. The NGF variants of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the NGF variant neurotrophins are also provided.
公开/授权文献
- US08101571B2 Treatment methods using NGF variants 公开/授权日：2012-01-24