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公开(公告)号：US08101571B2
公开(公告)日：2012-01-24
申请号：US12254458
申请日：2008-10-20
申请人： Leonard G. Presta , Roman Urfer , John W. Winslow
发明人： Leonard G. Presta , Roman Urfer , John W. Winslow
IPC分类号： A61K38/18
摘要： NGF variants which have trkC-binding activity and trkC-signal inducing activity are provided. The variants optionally have trkA or trkB binding and signal induction activity. The NGF variants of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the NGF variant neurotrophins are also provided.
摘要翻译： 提供具有trkC结合活性和trkC信号诱导活性的NGF变体。 变体任选具有trkA或trkB结合和信号诱导活性。 本发明的NGF变体可用于治疗神经元疾病。 还提供了编码NGF变体神经营养蛋白的核酸和表达载体。
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公开(公告)号：US07452863B1
公开(公告)日：2008-11-18
申请号：US09066619
申请日：1998-04-24
申请人： Leonard G. Presta , Roman Urfer , John W. Winslow
发明人： Leonard G. Presta , Roman Urfer , John W. Winslow
摘要： NGF variants which have trkC-binding activity and trkC-signal inducing activity are provided. The variants optionally have trkA or trkB binding and signal induction activity. The NGF variants of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the NGF variant neurotrophins are also provided.
摘要翻译： 提供具有trkC结合活性和trkC信号诱导活性的NGF变体。 变体任选具有trkA或trkB结合和信号诱导活性。 本发明的NGF变体可用于治疗神经元疾病。 还提供了编码NGF变体神经营养蛋白的核酸和表达载体。
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公开(公告)号：US07935671B2
公开(公告)日：2011-05-03
申请号：US12401483
申请日：2009-03-10
申请人： Roman Urfer , Leonard G. Presta , John W. Winslow
发明人： Roman Urfer , Leonard G. Presta , John W. Winslow
IPC分类号： A61K38/18 , C07K14/475 , C07K14/48
CPC分类号： A61K38/185 , C07K14/475 , C07K14/48 , C12N15/11
摘要： Pantropic neurotrophic factors which have multiple neurotrophic specificities are provided. The pantropic neurotrophic factors of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the pantropic neurotrophins are also provided.
摘要翻译： 提供了具有多种神经营养特异性的泛性神经营养因子。 本发明的泛素神经营养因子可用于治疗神经元疾病。 还提供了编码泛素神经营养因子的核酸和表达载体。
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公开(公告)号：US07528233B2
公开(公告)日：2009-05-05
申请号：US11443576
申请日：2006-05-30
申请人： Roman Urfer , Leonard G. Presta , John W. Winslow
发明人： Roman Urfer , Leonard G. Presta , John W. Winslow
IPC分类号： A61K38/18 , C07K14/475 , C07K14/48
CPC分类号： A61K38/185 , C07K14/475 , C07K14/48 , C12N15/11
摘要： Pantropic neurotrophic factors which have multiple neurotrophic specificities are provided. The pantropic neurotrophic factors of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the pantropic neurotrophins are also provided.
摘要翻译： 提供了具有多种神经营养特异性的泛性神经营养因子。 本发明的泛素神经营养因子可用于治疗神经元疾病。 还提供了编码泛素神经营养因子的核酸和表达载体。
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公开(公告)号：US5728803A
公开(公告)日：1998-03-17
申请号：US440049
申请日：1995-05-12
申请人： Roman Urfer , Leonard G. Presta , John W. Winslow
发明人： Roman Urfer , Leonard G. Presta , John W. Winslow
IPC分类号： C12N15/09 , A61K38/18 , A61K38/27 , A61P25/00 , C07H21/04 , C07K14/475 , C07K14/48 , C12N5/10 , C12N15/11 , C12N15/18 , C12P21/02
CPC分类号： A61K38/185 , C07K14/475 , C07K14/48 , C12N15/11
摘要： Pantropic neurotrophic factors which have multiple neurotrophic specificities are provided. The pantropic neurotrophic factors of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the pantropic neurotrophins are also provided.
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公开(公告)号：US07144983B1
公开(公告)日：2006-12-05
申请号：US10230865
申请日：2002-08-28
申请人： Roman Urfer , Leonard G. Presta , John W. Winslow
发明人： Roman Urfer , Leonard G. Presta , John W. Winslow
CPC分类号： C07K14/475 , C07K14/4756 , C07K14/48
摘要： Pantropic neurotrophic factors which have multiple neurotrophic specificities are provided. The pantropic neurotrophic factors of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the pantropic neurotrophins are also provided.
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公开(公告)号：US06503728B1
公开(公告)日：2003-01-07
申请号：US08794028
申请日：1997-02-03
申请人： Roman Urfer , Leonard G. Presta , John W. Winslow
发明人： Roman Urfer , Leonard G. Presta , John W. Winslow
IPC分类号： C12P2102
CPC分类号： A61K38/185 , C07K14/475 , C07K14/48 , C12N15/11
摘要： Pantropic neurotrophic factors which have multiple neurotrophic specificities are provided. The pantropic neurotrophic factors of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the pantropic neurotrophins are also provided.
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公开(公告)号：US06365373B2
公开(公告)日：2002-04-02
申请号：US09066065
申请日：1998-04-24
申请人： Leonard G. Presta , Roman Urfer , John W. Winslow
发明人： Leonard G. Presta , Roman Urfer , John W. Winslow
IPC分类号： C12N1518
摘要： NGF variants which have trkC-binding activity and trkC-signal inducing activity are provided. The variants optionally have trkA or trkB binding and signal induction activity. The NGF variants of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the NGF variant neurotrophins are also provided.
摘要翻译： 提供具有trkC结合活性和trkC信号诱导活性的NGF变体。 变体任选具有trkA或trkB结合和信号诱导活性。 本发明的NGF变体可用于治疗神经元疾病。 还提供了编码NGF变体神经营养蛋白的核酸和表达载体。
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公开(公告)号：US20090137471A1
公开(公告)日：2009-05-28
申请号：US12254458
申请日：2008-10-20
申请人： Leonard G. Presta , Roman Urfer , John W. Winslow
发明人： Leonard G. Presta , Roman Urfer , John W. Winslow
IPC分类号： A61K38/18 , C07K14/48 , C12N15/12 , A61P25/00 , C12N1/15 , C12N5/10 , C12N1/19 , C12N1/21 , C12N15/63 , C12P21/00
摘要： NGF variants which have trkC-binding activity and trkC-signal inducing activity are provided. The variants optionally have trkA or trkB binding and signal induction activity. The NGF variants of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the NGF variant neurotrophins are also provided.
摘要翻译： 提供具有trkC结合活性和trkC信号诱导活性的NGF变体。 变体任选具有trkA或trkB结合和信号诱导活性。 本发明的NGF变体可用于治疗神经元疾病。 还提供了编码NGF变体神经营养蛋白的核酸和表达载体。
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公开(公告)号：US06333310B1
公开(公告)日：2001-12-25
申请号：US08845541
申请日：1997-04-25
申请人： Leonard G. Presta , Roman Urfer , John W. Winslow
发明人： Leonard G. Presta , Roman Urfer , John W. Winslow
IPC分类号： A61K3818
CPC分类号： A61K38/185 , C07K14/475 , C07K14/48 , C12N15/11
摘要： NGF variants which have trkC-binding activity and trkC-signal inducing activity are provided. The variants optionally have trkA or trkB binding and signal induction activity. The NGF variants of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the NGF variant neurotrophins are also provided.
摘要翻译： 提供具有trkC结合活性和trkC信号诱导活性的NGF变体。 变体任选具有trkA或trkB结合和信号诱导活性。 本发明的NGF变体可用于治疗神经元疾病。 还提供了编码NGF变体神经营养蛋白的核酸和表达载体。
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