发明申请
US20090137517A1 SENSITIZING A CELL TO CANCER TREATMENT BY MODULATING THE ACTIVITY OF A NUCLEIC ACID ENCODING RPS27L PROTEIN
审中-公开
通过调节核酸编码RPS27L蛋白的活性来感染癌症治疗细胞
- 专利标题： SENSITIZING A CELL TO CANCER TREATMENT BY MODULATING THE ACTIVITY OF A NUCLEIC ACID ENCODING RPS27L PROTEIN
- 专利标题（中）： 通过调节核酸编码RPS27L蛋白的活性来感染癌症治疗细胞
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申请号： US12281423申请日： 2007-03-01
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公开(公告)号： US20090137517A1公开(公告)日： 2009-05-28
- 发明人: Qiang Yu
- 申请人： Qiang Yu
- 申请人地址： SG Centros
- 专利权人： Agency for Science, Technology and Research
- 当前专利权人： Agency for Science, Technology and Research
- 当前专利权人地址： SG Centros
- 国际申请： PCT/SG07/00058 WO 20070301
- 主分类号： A61K31/7105
- IPC分类号： A61K31/7105 ; C12N5/06 ; C12N15/00
摘要：
The present invention refers to a method of sensitizing a cell to cancer treatment comprising modulating the activity of a nucleic acid which encodes the RPS27L protein by use of an oligonucleotide which is a RNAi agent or an antisense nucleotide molecule. The oligonucleotides of the present invention can be used in combination with at least one cytostatic drug for, e.g., chemotherapy. The present invention further refers to an expression vector comprising an oligonucleotide used in the method of the present invention as well as to a pharmaceutical comprising the oligonucleotides together with at least one chemotherapeutic agent used in the method of the present invention.