发明申请
US20090142317A1 PROCESS FOR REDUCING EFFECTS OF GRAFT VERSUS HOST DISEASE USING EX VIVO EXPANDED CD4+CD25+ REGULATORY T CELLS
审中-公开
使用EX VIVO扩增的CD4 + CD25 +调节性T细胞减少病毒性疾病的影响的方法
- 专利标题： PROCESS FOR REDUCING EFFECTS OF GRAFT VERSUS HOST DISEASE USING EX VIVO EXPANDED CD4+CD25+ REGULATORY T CELLS
- 专利标题（中）： 使用EX VIVO扩增的CD4 + CD25 +调节性T细胞减少病毒性疾病的影响的方法
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申请号： US12325464申请日： 2008-12-01
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公开(公告)号： US20090142317A1公开(公告)日： 2009-06-04
- 发明人: Tinghua Cao , Li Li
- 申请人： Tinghua Cao , Li Li
- 专利权人： Therakos, Inc.
- 当前专利权人： Therakos, Inc.
- 主分类号： A61K35/12
- IPC分类号： A61K35/12
摘要：
Disclosed in this specification is a process for producing ex vivo expanded CD4+CD25+ regulatory T cells. The process includes the steps of extracting a sample that includes peripheral blood mononuclear cells from a human donor. The extracted cells include a certain number of cells which are CD4+CD25+ regulatory T cells. The relative population of the CD4+CD25+ regulatory T cells is enhanced such that the Treg cells constitute the majority of the cells in the sample. Thereafter, the population of the enriched Treg cells, that may include third-party derived Treg cells, is expanded to produce a clinically meaningful population of cells for use in the treatment of GVHD.
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