公开(公告)号：US20240360227A1

公开(公告)日：2024-10-31

申请号：US18760539

申请日：2024-07-01

申请人： Viridian Therapeutics, Inc.

发明人： Vahe BEDIAN ,  Yang ZHAO

IPC分类号： C07K16/28 ,  A61K31/7088 ,  A61K35/12 ,  A61P27/02 ,  C07K16/46

CPC分类号： C07K16/2863 ,  A61K31/7088 ,  A61K35/12 ,  A61P27/02 ,  C07K16/461 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/94

摘要： Antibodies and compositions against IGF-1R and uses thereof are provided herein.

公开(公告)号：US20240344027A1

公开(公告)日：2024-10-17

申请号：US18587729

申请日：2024-02-26

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Everett Hurteau Meyer ,  Robert S. Negrin

IPC分类号： C12N5/0789 ,  A61K31/436 ,  A61K31/445 ,  A61K35/12 ,  A61K35/17 ,  A61K35/28 ,  A61K39/00 ,  A61P35/02 ,  A61P37/06 ,  C12N5/0783

CPC分类号： C12N5/0647 ,  A61K31/436 ,  A61K31/445 ,  A61K35/17 ,  A61K35/28 ,  A61K39/001 ,  A61P35/02 ,  A61P37/06 ,  C12N5/0637 ,  A61K2035/122 ,  C12N2506/11

摘要： The disclosure provides methods for improved hematopoietic stem cell transplantations, including methods to enhance protection from graft versus host disease while maintaining effective immune responses such as graft versus tumor immune responses. The disclosure provides methods for administering, for example, hematopoietic stem and progenitor cells, regulatory T cells, and conventional T cells, wherein the conventional T cells are administered after the hematopoietic stem and progenitor cells and regulatory T cells. The disclosure also provides methods for administering, for example, hematopoietic stem and progenitor cells, regulatory T cells, and conventional T cells, wherein the regulatory T cells have not been cryopreserved prior to administration.

公开(公告)号：US12119101B2

公开(公告)日：2024-10-15

申请号：US18054421

申请日：2022-11-10

申请人： CENTERLINE BIOMEDICAL, INC.

发明人： Matthew Holladay ,  Vikash Goel

IPC分类号： G06K9/00 ,  A61K35/12 ,  G02B27/01 ,  G06T7/00 ,  G06T19/00 ,  G16H30/20

CPC分类号： G16H30/20 ,  G02B27/017 ,  G06T7/0012 ,  G06T7/97 ,  G06T19/006

摘要： An example method may include acquiring images from cameras, each having a known position and orientation with respect to a spatial coordinate system of an augmented reality (AR) device. The acquired images may include portions of a multi-modal marker device that includes at least one tracking sensor having a three-dimensional position that is detectable in a coordinate system of a tracking system. A three-dimensional position is estimated for the portions of the multi-modal marker device with respect to the spatial coordinate system of the AR device based on each of the respective acquired images and the known position and orientation of the cameras with respect to the spatial coordinate system of the AR device. The method also includes computing an affine transform configured to register the coordinate system of the tracking system with a visual space of a display that is in the spatial coordinate system of the AR device.

公开(公告)号：US12102652B2

公开(公告)日：2024-10-01

申请号：US16326270

申请日：2017-08-11

申请人： Baylor College of Medicine

发明人： Thomas C. T. Shum ,  Stephen M. G. Gottschalk ,  Bilal Omer ,  Cliona M. Rooney

IPC分类号： C07K14/715 ,  A61K35/12 ,  A61K35/17 ,  A61K39/00 ,  A61P35/00 ,  C07K14/00 ,  C07K14/47 ,  C07K14/725 ,  C12N15/85 ,  A61K38/00

CPC分类号： A61K35/17 ,  A61K35/12 ,  A61K39/001119 ,  A61P35/00 ,  C07K14/00 ,  C07K14/4748 ,  C07K14/7051 ,  C07K14/715 ,  C07K14/7155 ,  C12N15/85 ,  A61K38/00

摘要： Embodiments of the disclosure include methods and compositions for enhancing expansion of immune cells for immunotherapy. In particular embodiments, immune cells, such as T-cells, express a constitutively active cytokine receptor in which the transmembrane and endodomains are able to provide an activating signal separately from any input to the corresponding exodomain to which they are operably linked. In specific embodiments, the transmembrane and endodomain from IL-7Rα is utilized with the exodomain of CD34.

公开(公告)号：US20240316171A1

公开(公告)日：2024-09-26

申请号：US18585659

申请日：2024-02-23

申请人： Dana-Farber Cancer Institute, Inc.

发明人： Carl Novina ,  Robert Distel ,  Alberto Nobili ,  Steven Neier

IPC分类号： A61K39/00 ,  A61K35/12 ,  A61K35/17 ,  A61K38/17 ,  A61K39/385 ,  A61K41/00 ,  A61K45/06 ,  A61K47/54 ,  A61K47/68

CPC分类号： A61K39/0013 ,  A61K35/17 ,  A61K38/1774 ,  A61K39/385 ,  A61K41/0042 ,  A61K41/0057 ,  A61K45/06 ,  A61K47/545 ,  A61K47/555 ,  A61K47/6889 ,  A61K47/6897 ,  A61K2035/124

摘要： The present invention provides universal immunotherapy compositions useful for targeted treatment of cancers.

公开(公告)号：US20240316111A1

公开(公告)日：2024-09-26

申请号：US18734900

申请日：2024-06-05

申请人： Christian VAN DEN BOS

发明人： Christian VAN DEN BOS ,  Barbara REINISCH ,  Judith SCHENK ,  Claudia ROSENBAUM

IPC分类号： A61K35/28 ,  A61K31/437 ,  A61K35/12 ,  C12N15/11 ,  C12N15/113

CPC分类号： A61K35/28 ,  A61K31/437 ,  C12N15/111 ,  C12N15/113 ,  A61K2035/124 ,  A61K2300/00 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2310/141 ,  C12N2320/31

摘要： The invention encompasses compositions and method of treating a vascular disease such as peripheral artery disease, The methods involve—administering to a patient in need thereof, an effective amount of a composition comprising a population of cells such as mesenchymal stem cells (MSCs) and a non-muscle myosin 0 antagonist such as blebbistatin. Non-muscle myosin II antagonists are disclosed to surprisingly and dramatically accelerate MSC-triggered regeneration of damaged tissues arid unexpectedly and drastically reduce severe complications of stem cell treatment.

公开(公告)号：US20240316101A1

公开(公告)日：2024-09-26

申请号：US18421039

申请日：2024-01-24

申请人： EpiVax Inc.

发明人： Anne De Groot ,  William Martin

IPC分类号： A61K35/17 ,  A61K35/12 ,  C07K7/08 ,  C12N5/0783

CPC分类号： A61K35/17 ,  C07K7/08 ,  C12N5/0637 ,  A61K2035/122

摘要： The present is directed to compositions comprising regulatory T cell epitopes, wherein said epitopes comprises a polypeptide comprising at least a portion of SEQ NOS: 1-124 (and/or fragments and variants thereof), and optionally 1 to 12 additional amino acids distributed in any ratio on the N-terminus and/or C-terminus of the polypeptide of SEQ ID NOS: 1-124, as well as methods of producing and using the same.

公开(公告)号：US12094324B2

公开(公告)日：2024-09-17

申请号：US18460811

申请日：2023-09-05

申请人： Navio International, Inc.

发明人： Ernest C. Brown

IPC分类号： A61K35/12 ,  F21S2/00 ,  F21S8/08 ,  G05D1/00 ,  G06V20/52 ,  G08B25/08 ,  G08B25/10 ,  H04L67/125 ,  H04W4/38 ,  H04W4/50 ,  H04W4/70 ,  H04W4/90 ,  F21W131/10 ,  H04W84/18

CPC分类号： G08B25/10 ,  F21S2/005 ,  F21S8/088 ,  G05D1/0022 ,  G06V20/52 ,  G08B25/08 ,  H04L67/125 ,  H04W4/38 ,  H04W4/50 ,  H04W4/70 ,  H04W4/90 ,  F21W2131/10 ,  H04W84/18

摘要： A system for sensing and responding to detected activity or an event in a region is provided. The system may comprise: a modular edge computing platform configured to provide a predetermined functionality for a particular application, the modular edge computing platform is configured to process sensor data to generate processed data, and transmit the processed data; and a remote entity that comprises (i) a cloud analytic configured to receive the processed data from the modular edge computing platform and analyze the processed data, and (ii) a cloud user interface module configured to provide a graphical user interface on a user device, the graphical user interface displays one or more results generated by the cloud analytic upon analyzing the processed data.

公开(公告)号：US12084522B2

公开(公告)日：2024-09-10

申请号：US17339157

申请日：2021-06-04

申请人： Immatics Biotechnologies GmbH

发明人： Andrea Mahr ,  Toni Weinschenk ,  Colette Song ,  Oliver Schoor ,  Jens Fritsche ,  Harpreet Singh

IPC分类号： C07K16/18 ,  A61K35/17 ,  A61K39/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/47 ,  C07K14/725 ,  C12N15/115 ,  G01N33/68 ,  A61K35/12

CPC分类号： C07K7/08 ,  A61K35/17 ,  A61K39/0011 ,  C07K7/06 ,  C07K14/4748 ,  C07K14/7051 ,  C07K16/18 ,  C12N15/115 ,  G01N33/6893 ,  A61K2035/124 ,  A61K2039/5154 ,  A61K2039/80 ,  A61K2039/804 ,  A61K2039/812 ,  A61K2039/82 ,  A61K2039/828 ,  A61K2039/836 ,  A61K2039/844 ,  A61K2039/852 ,  A61K2039/86 ,  A61K2039/868 ,  A61K2039/876 ,  A61K2039/884 ,  A61K2039/892 ,  C07K2319/00 ,  C12N2310/16 ,  G01N2800/52

摘要： The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.

公开(公告)号：US12076380B2

公开(公告)日：2024-09-03

申请号：US17492112

申请日：2021-10-01

申请人： IMMATICS BIOTECHNOLOGIES GMBH

发明人： Toni Weinschenk ,  Andrea Mahr ,  Jens Fritsche ,  Phillip Mueller ,  Anita Wiebe ,  Sarah Kutscher

IPC分类号： A61K39/00 ,  A61K35/17 ,  A61K38/04 ,  C07K7/00 ,  C07K7/06 ,  C07K14/435 ,  C07K14/725 ,  C07K14/74 ,  C07K16/18 ,  C12N5/0783 ,  C12N15/115 ,  A61K35/12 ,  A61K51/10 ,  C07K7/08 ,  G01N33/68

CPC分类号： A61K39/0011 ,  A61K35/17 ,  A61K38/04 ,  C07K7/00 ,  C07K7/06 ,  C07K14/435 ,  C07K14/7051 ,  C07K14/70539 ,  C07K16/18 ,  C12N5/0636 ,  C12N15/115 ,  A61K2035/124 ,  A61K39/00111 ,  A61K2039/5154 ,  A61K2039/5158 ,  A61K51/1057 ,  C07K7/08 ,  C07K2317/70 ,  C07K2319/40 ,  C12N2310/16 ,  C12N2501/998 ,  G01N33/6803

摘要： A peptide consists of the amino acid sequence ALVEQGFTV (SEQ ID NO: 5) in the form of a pharmaceutically acceptable salt, in which the peptide has the ability to bind to an MHC class-I molecule and, when bound to MHC, is capable of being recognized by CD8+ T cells. A composition contains a peptide consisting of the amino acid sequence ALVEQGFTV (SEQ ID NO: 5), an adjuvant, and a pharmaceutically acceptable carrier.