Invention Application
US20090143408A1 COMPOSITIONS AND METHODS FOR INHIBITING CYTOCHROME P450 2D6
有权
抑制细胞色素P450 2D6的组合物和方法
- Patent Title: COMPOSITIONS AND METHODS FOR INHIBITING CYTOCHROME P450 2D6
- Patent Title (中): 抑制细胞色素P450 2D6的组合物和方法
-
Application No.: US12324507Application Date: 2008-11-26
-
Publication No.: US20090143408A1Publication Date: 2009-06-04
- Inventor: Michael EISSENSTAT , Dehui Duan , Ji-Hye Kang
- Applicant: Michael EISSENSTAT , Dehui Duan , Ji-Hye Kang
- Applicant Address: US MD Gaithersburg
- Assignee: Sequoia Pharmaceuticals, Inc.
- Current Assignee: Sequoia Pharmaceuticals, Inc.
- Current Assignee Address: US MD Gaithersburg
- Main IPC: A61K31/497
- IPC: A61K31/497 ; C07D307/78 ; C07D407/12 ; C07D405/12 ; C12N9/99 ; A61K31/343 ; A61K31/443
Abstract:
Methods of inhibiting cytochrome P450 2D6 enzymes are provided that can be used for improving the treatment of diseases by preventing degradation of drugs or other molecules by cytochrome P450 2D6. Pharmaceutical compositions are provided that can act as boosters to improve the pharmacokinetics, enhance the bioavailability, and enhance the therapeutic effect of drugs that undergo in vivo degradation by cytochrome P450 2D6 enzymes.
Public/Granted literature
- US08569364B2 5-substituted benzofurans as inhibitors of cytochrome P450 2D6 Public/Granted day:2013-10-29
Information query
IPC分类:
